Abstract
In addition to the direct neutralization of virus, there is a broader potential for antibody-mediated inhibition of human immunodeficiency virus (HIV) by targeting HFV to effector cells. We demonstrate here that a bispecific antibody incorporating a broadly reactive anti-gp41 antibody, F240, and an anti-IgA receptor (CD89) antibody is effective at directing neutrophils to destroy HFV. Not only are neutrophils the predominant type of white blood cells and very efficient at mediating cell cytotoxicity, they are relatively resistant to infection with HFV. Therefore, they represent a significant weapon against infection if they can be directed and armed to destroy HIV and infected cells.
| Original language | English |
|---|---|
| Pages (from-to) | 4671-4674 |
| Number of pages | 4 |
| Journal | Journal of Virology |
| Volume | 82 |
| Issue number | 9 |
| DOIs | |
| State | Published - May 2008 |
| Externally published | Yes |