A bioinformatic assay for pluripotency in human cells

Franz Josef Müller, Bernhard M. Schuldt, Roy Williams, Dylan Mason, Gulsah Altun, Eirini P. Papapetrou, Sandra Danner, Johanna E. Goldmann, Arne Herbst, Nils O. Schmidt, Josef B. Aldenhoff, Louise C. Laurent, Jeanne F. Loring

Research output: Contribution to journalArticlepeer-review

351 Scopus citations

Abstract

Pluripotent stem cells (PSCs) are defined by their potential to generate all cell types of an organism. The standard assay for pluripotency of mouse PSCs is cell transmission through the germline, but for human PSCs researchers depend on indirect methods such as differentiation into teratomas in immunodeficient mice. Here we report PluriTest, a robust open-access bioinformatic assay of pluripotency in human cells based on their gene expression profiles.

Original languageEnglish
Pages (from-to)315-317
Number of pages3
JournalNature Methods
Volume8
Issue number4
DOIs
StatePublished - Apr 2011
Externally publishedYes

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