TY - JOUR
T1 - A biodegradeable membrane from porcine intestinal submucosa to reinforce the gastrojejunostomy in laparoscopic Roux-en-Y gastric bypass
T2 - Preliminary report
AU - Kini, Subhash
PY - 2001
Y1 - 2001
N2 - Background: A Silastic ring has been used to prevent dilation of the gastrojejunostomy in Roux-en-Y gastric bypass (RYGBP). The use of a bio-membrane may prevent dilation of the anastomosis without the risks associated with prostheses. The aim of this study was to evaluate the feasibility and safety of applying such a bio-membrane around the gastrojejunostomy in Laparoscopic RYGBP (LRYGBP). Methods: We used a new bio-membrane, that is derived from porcine small intestinal submucosa (SIS) and acts as a scaffolding for the ingrowth of connective tissue. Over a 4-month period, 14 LRYGBP patients had their proximal anastomosis wrapped with 10 × 2.5 cm SIS by a single surgeon. We compared these patients to a control group of LRYGBP patients matched for BMI. Results: The average age of the patients was 35.0 years (control group: 45.1 years). The patients had a mean initial BMI of 44.7 kg/m2 (±5.9) standard error, and the control subjects had a mean initial BMI of 46.7 kg/m2 (±6.5). SIS application took a mean time of 11 (±3) minutes without any intraoperative complication. The median hospital stay was 3.5 days in the experimental group and 3.7 days in controls. Three patients developed a symptomatic stenosis at the gastrojejunostomy following surgery. In the control group there were two stenoses. At an average follow-up of 87 days (controls: 95 days), the mean reduction in BMI was 7.8 (± 0.8) kg/m2 [controls 8.6 kg/m2 (± 1.5)]. Conclusion: Application of SIS around the gastrojejunostomy in patients undergoing LRYGBP is feasible and safe. Further follow-up is required, however, to evaluate the effectiveness in preventing dilation of the anastomosis.
AB - Background: A Silastic ring has been used to prevent dilation of the gastrojejunostomy in Roux-en-Y gastric bypass (RYGBP). The use of a bio-membrane may prevent dilation of the anastomosis without the risks associated with prostheses. The aim of this study was to evaluate the feasibility and safety of applying such a bio-membrane around the gastrojejunostomy in Laparoscopic RYGBP (LRYGBP). Methods: We used a new bio-membrane, that is derived from porcine small intestinal submucosa (SIS) and acts as a scaffolding for the ingrowth of connective tissue. Over a 4-month period, 14 LRYGBP patients had their proximal anastomosis wrapped with 10 × 2.5 cm SIS by a single surgeon. We compared these patients to a control group of LRYGBP patients matched for BMI. Results: The average age of the patients was 35.0 years (control group: 45.1 years). The patients had a mean initial BMI of 44.7 kg/m2 (±5.9) standard error, and the control subjects had a mean initial BMI of 46.7 kg/m2 (±6.5). SIS application took a mean time of 11 (±3) minutes without any intraoperative complication. The median hospital stay was 3.5 days in the experimental group and 3.7 days in controls. Three patients developed a symptomatic stenosis at the gastrojejunostomy following surgery. In the control group there were two stenoses. At an average follow-up of 87 days (controls: 95 days), the mean reduction in BMI was 7.8 (± 0.8) kg/m2 [controls 8.6 kg/m2 (± 1.5)]. Conclusion: Application of SIS around the gastrojejunostomy in patients undergoing LRYGBP is feasible and safe. Further follow-up is required, however, to evaluate the effectiveness in preventing dilation of the anastomosis.
KW - Gastrojejunostomy
KW - Laparoscopy
KW - Morbid obesity
KW - Roux-en-Y gastric bypass
KW - Small intestinal submucosa
UR - http://www.scopus.com/inward/record.url?scp=0034925426&partnerID=8YFLogxK
U2 - 10.1381/096089201321209350
DO - 10.1381/096089201321209350
M3 - Article
C2 - 11501357
AN - SCOPUS:0034925426
SN - 0960-8923
VL - 11
SP - 469
EP - 473
JO - Obesity Surgery
JF - Obesity Surgery
IS - 4
M1 - 68
ER -