A 64-Year-Old Woman with Progressive Pain, Numbness and Weakness in the Right Lower Limb

Lan Zhou; Susan Morgello; Rajeev Motiwala; Susan C. Shin

doi:10.1007/978-3-030-25682-1_37

A 64-Year-Old Woman with Progressive Pain, Numbness and Weakness in the Right Lower Limb

Lan Zhou
, Susan Morgello
, Rajeev Motiwala
, Susan C. Shin

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

We describe a case of primary neurolymphomatosis (PNL) with unusual presentation of a right lumbosacral polyradiculoneuropathy with no other lesions shown on the whole body fludeoxyglucose-positron emission tomography (FDG-PET) scan. A right superficial peroneal nerve lesion biopsy revealed infiltration of the nerve by malignant CD20+ lymphoma cells. The lymphoma cells expressed Bcl-2 but not CD10, suggesting an origin in peripheral blood not lymph nodes. The patient responded very well to the combined radiotherapy and chemotherapy with the R-MPV (rituximab, methotrexate, procarbazine, and vincristine) regimen. The patient showed marked clinical improvement and complete resolution of lymphoma lesions on the PET scan.

Original language	English
Title of host publication	A Case-Based Guide to Neuromuscular Pathology
Publisher	Springer Science+Business Media
Pages	349-356
Number of pages	8
ISBN (Electronic)	9783030256821
ISBN (Print)	9783030256814
DOIs	https://doi.org/10.1007/978-3-030-25682-1_37
State	Published - 1 Jan 2019

Keywords

Diffuse large B-cell lymphoma
Nerve biopsy
Neurolymphomatosis
Polyradiculoneuropathy

Access to Document

10.1007/978-3-030-25682-1_37

Cite this

@inbook{624a69167dc14a479ac18af8248d3256,

title = "A 64-Year-Old Woman with Progressive Pain, Numbness and Weakness in the Right Lower Limb",

abstract = "We describe a case of primary neurolymphomatosis (PNL) with unusual presentation of a right lumbosacral polyradiculoneuropathy with no other lesions shown on the whole body fludeoxyglucose-positron emission tomography (FDG-PET) scan. A right superficial peroneal nerve lesion biopsy revealed infiltration of the nerve by malignant CD20+ lymphoma cells. The lymphoma cells expressed Bcl-2 but not CD10, suggesting an origin in peripheral blood not lymph nodes. The patient responded very well to the combined radiotherapy and chemotherapy with the R-MPV (rituximab, methotrexate, procarbazine, and vincristine) regimen. The patient showed marked clinical improvement and complete resolution of lymphoma lesions on the PET scan.",

keywords = "Diffuse large B-cell lymphoma, Nerve biopsy, Neurolymphomatosis, Polyradiculoneuropathy",

author = "Lan Zhou and Susan Morgello and Rajeev Motiwala and Shin, \{Susan C.\}",

note = "Publisher Copyright: {\textcopyright} Springer Nature Switzerland AG 2020.",

year = "2019",

month = jan,

day = "1",

doi = "10.1007/978-3-030-25682-1\_37",

language = "English",

isbn = "9783030256814",

pages = "349--356",

booktitle = "A Case-Based Guide to Neuromuscular Pathology",

publisher = "Springer Science+Business Media",

}

TY - CHAP

T1 - A 64-Year-Old Woman with Progressive Pain, Numbness and Weakness in the Right Lower Limb

AU - Zhou, Lan

AU - Morgello, Susan

AU - Motiwala, Rajeev

AU - Shin, Susan C.

N1 - Publisher Copyright: © Springer Nature Switzerland AG 2020.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - We describe a case of primary neurolymphomatosis (PNL) with unusual presentation of a right lumbosacral polyradiculoneuropathy with no other lesions shown on the whole body fludeoxyglucose-positron emission tomography (FDG-PET) scan. A right superficial peroneal nerve lesion biopsy revealed infiltration of the nerve by malignant CD20+ lymphoma cells. The lymphoma cells expressed Bcl-2 but not CD10, suggesting an origin in peripheral blood not lymph nodes. The patient responded very well to the combined radiotherapy and chemotherapy with the R-MPV (rituximab, methotrexate, procarbazine, and vincristine) regimen. The patient showed marked clinical improvement and complete resolution of lymphoma lesions on the PET scan.

AB - We describe a case of primary neurolymphomatosis (PNL) with unusual presentation of a right lumbosacral polyradiculoneuropathy with no other lesions shown on the whole body fludeoxyglucose-positron emission tomography (FDG-PET) scan. A right superficial peroneal nerve lesion biopsy revealed infiltration of the nerve by malignant CD20+ lymphoma cells. The lymphoma cells expressed Bcl-2 but not CD10, suggesting an origin in peripheral blood not lymph nodes. The patient responded very well to the combined radiotherapy and chemotherapy with the R-MPV (rituximab, methotrexate, procarbazine, and vincristine) regimen. The patient showed marked clinical improvement and complete resolution of lymphoma lesions on the PET scan.

KW - Diffuse large B-cell lymphoma

KW - Nerve biopsy

KW - Neurolymphomatosis

KW - Polyradiculoneuropathy

UR - https://www.scopus.com/pages/publications/105009073358

U2 - 10.1007/978-3-030-25682-1_37

DO - 10.1007/978-3-030-25682-1_37

M3 - Chapter

AN - SCOPUS:105009073358

SN - 9783030256814

SP - 349

EP - 356

BT - A Case-Based Guide to Neuromuscular Pathology

PB - Springer Science+Business Media

ER -

A 64-Year-Old Woman with Progressive Pain, Numbness and Weakness in the Right Lower Limb

Abstract

Keywords

Access to Document

Fingerprint

Cite this