A 45-Year-Old Woman with Proximal Limb Weakness and Skin Peeling on Fingertips

Lan Zhou; Susan C. Shin; Chunyu Cai

doi:10.1007/978-3-030-25682-1_5

A 45-Year-Old Woman with Proximal Limb Weakness and Skin Peeling on Fingertips

Lan Zhou
, Susan C. Shin
, Chunyu Cai

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Based on the clinical presentation, autoantibody association, and muscle biopsy features, idiopathic inflammatory myopathies are currently classified into fiver distinct subtypes: inclusion body myositis, polymyositis, dermatomyositis, immune-mediated necrotizing myopathy, and antisynthetase syndrome. Antisynthetase syndrome is characterized by the presence of anti-tRNA synthetase autoantibodies, myositis, interstitial lung disease, arthralgia, mechanic’s hands, and Raynaud's phenomenon. Here, we describe a case of antisynthetase syndrome associated with anti-Jo-1 autoantibody to illustrate the clinical and muscle biopsy features.

Original language	English
Title of host publication	A Case-Based Guide to Neuromuscular Pathology
Publisher	Springer Science+Business Media
Pages	97-108
Number of pages	12
ISBN (Electronic)	9783030256821
ISBN (Print)	9783030256814
DOIs	https://doi.org/10.1007/978-3-030-25682-1_5
State	Published - 1 Jan 2019

Keywords

Antisynthetase syndrome
Idiopathic inflammatory myopathies
Jo-1 antibody
Mechanic’s hand
Perifascicular necrosis
Perimysium pathology

Access to Document

10.1007/978-3-030-25682-1_5

Cite this

@inbook{9123184d7e00476e99791162143427af,

title = "A 45-Year-Old Woman with Proximal Limb Weakness and Skin Peeling on Fingertips",

abstract = "Based on the clinical presentation, autoantibody association, and muscle biopsy features, idiopathic inflammatory myopathies are currently classified into fiver distinct subtypes: inclusion body myositis, polymyositis, dermatomyositis, immune-mediated necrotizing myopathy, and antisynthetase syndrome. Antisynthetase syndrome is characterized by the presence of anti-tRNA synthetase autoantibodies, myositis, interstitial lung disease, arthralgia, mechanic{\textquoteright}s hands, and Raynaud's phenomenon. Here, we describe a case of antisynthetase syndrome associated with anti-Jo-1 autoantibody to illustrate the clinical and muscle biopsy features.",

keywords = "Antisynthetase syndrome, Idiopathic inflammatory myopathies, Jo-1 antibody, Mechanic{\textquoteright}s hand, Perifascicular necrosis, Perimysium pathology",

author = "Lan Zhou and Shin, \{Susan C.\} and Chunyu Cai",

note = "Publisher Copyright: {\textcopyright} Springer Nature Switzerland AG 2020.",

year = "2019",

month = jan,

day = "1",

doi = "10.1007/978-3-030-25682-1\_5",

language = "English",

isbn = "9783030256814",

pages = "97--108",

booktitle = "A Case-Based Guide to Neuromuscular Pathology",

publisher = "Springer Science+Business Media",

}

TY - CHAP

T1 - A 45-Year-Old Woman with Proximal Limb Weakness and Skin Peeling on Fingertips

AU - Zhou, Lan

AU - Shin, Susan C.

AU - Cai, Chunyu

N1 - Publisher Copyright: © Springer Nature Switzerland AG 2020.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Based on the clinical presentation, autoantibody association, and muscle biopsy features, idiopathic inflammatory myopathies are currently classified into fiver distinct subtypes: inclusion body myositis, polymyositis, dermatomyositis, immune-mediated necrotizing myopathy, and antisynthetase syndrome. Antisynthetase syndrome is characterized by the presence of anti-tRNA synthetase autoantibodies, myositis, interstitial lung disease, arthralgia, mechanic’s hands, and Raynaud's phenomenon. Here, we describe a case of antisynthetase syndrome associated with anti-Jo-1 autoantibody to illustrate the clinical and muscle biopsy features.

AB - Based on the clinical presentation, autoantibody association, and muscle biopsy features, idiopathic inflammatory myopathies are currently classified into fiver distinct subtypes: inclusion body myositis, polymyositis, dermatomyositis, immune-mediated necrotizing myopathy, and antisynthetase syndrome. Antisynthetase syndrome is characterized by the presence of anti-tRNA synthetase autoantibodies, myositis, interstitial lung disease, arthralgia, mechanic’s hands, and Raynaud's phenomenon. Here, we describe a case of antisynthetase syndrome associated with anti-Jo-1 autoantibody to illustrate the clinical and muscle biopsy features.

KW - Antisynthetase syndrome

KW - Idiopathic inflammatory myopathies

KW - Jo-1 antibody

KW - Mechanic’s hand

KW - Perifascicular necrosis

KW - Perimysium pathology

UR - https://www.scopus.com/pages/publications/105009122723

U2 - 10.1007/978-3-030-25682-1_5

DO - 10.1007/978-3-030-25682-1_5

M3 - Chapter

AN - SCOPUS:105009122723

SN - 9783030256814

SP - 97

EP - 108

BT - A Case-Based Guide to Neuromuscular Pathology

PB - Springer Science+Business Media

ER -

A 45-Year-Old Woman with Proximal Limb Weakness and Skin Peeling on Fingertips

Abstract

Keywords

Access to Document

Fingerprint

Cite this