TY - JOUR
T1 - A 20-year Follow-up of the International Early Lung Cancer Action Program (I-ELCAP)
AU - The International Early Lung Cancer Action Program Investigators
AU - Henschke, Claudia I.
AU - Yip, Rowena
AU - Shaham, Dorith
AU - Markowitz, Steven
AU - Deval, José Cervera
AU - Zulueta, Javier J.
AU - Seijo, Luis M.
AU - Aylesworth, Cheryl
AU - Klingler, Karl
AU - Andaz, Shahriyour
AU - Chin, Cynthia
AU - Smith, James P.
AU - Taioli, Emanuela
AU - Altorki, Nasser
AU - Flores, Raja M.
AU - Yankelevitz, David F.
AU - Jirapatnakul, Artit
AU - Kaufman, Andrew
AU - Wolf, Andrea
AU - Nicastri, Daniel
AU - Harkin, Timothy
AU - Reeves, Anthony P.
AU - Libby, Daniel M.
AU - Pasmantier, Mark
AU - Miller, Albert
AU - Bastarika, Gorka
AU - Montuenga, Luis M.
AU - Schöb, Othmar
AU - Straznicka, Michaela
AU - Weiser, Todd
AU - Sone, Shusuke
AU - Hanaoka, Takaomi
AU - Roberts, Heidi
AU - Patsios, Demetris
AU - Scopetuolo, M.
AU - Brown, Andrew
AU - Bauer, Thomas
AU - Canitano, Stefano
AU - Giunta, Salvatore
AU - Wu, Ning
AU - Cole, Enser
AU - Meyers, Patrick
AU - Yeh, Diana
AU - Luedke, Dan
AU - Liu, Xueguo
AU - Herzog, Gary
AU - Aye, Ralph
AU - Korst, Robert
AU - Salvatore, Mary
AU - Connery, Cliff
N1 - Publisher Copyright:
© 2023 RSNA.
PY - 2023/11
Y1 - 2023/11
N2 - Background: The low-dose CT (≤3 mGy) screening report of 1000 Early Lung Cancer Action Program (ELCAP) participants in 1999 led to the International ELCAP (I-ELCAP) collaboration, which enrolled 31 567 participants in annual low-dose CT screening between 1992 and 2005. In 2006, I-ELCAP investigators reported the 10-year lung cancer.specific survival of 80% for 484 participants diagnosed with a first primary lung cancer through annual screening, with a high frequency of clinical stage I lung cancer (85%). Purpose: To update the cure rate by determining the 20-year lung cancer.specific survival of participants diagnosed with first primary lung cancer through annual low-dose CT screening in the expanded I-ELCAP cohort. Materials and Methods: For participants enrolled in the HIPAA-compliant prospective I-ELCAP cohort between 1992 and 2022 and observed until December 30, 2022, Kaplan-Meier survival analysis was used to determine the 10- and 20-year lung cancer.specific survival of participants diagnosed with first primary lung cancer through annual low-dose CT screening. Eligible participants were aged at least 40 years and had current or former cigarette use or had never smoked but had been exposed to secondhand tobacco smoke. Results: Among 89 404 I-ELCAP participants, 1257 (1.4%) were diagnosed with a first primary lung cancer (684 male, 573 female; median age, 66 years; IQR, 61.72), with a median smoking history of 43.0 pack-years (IQR, 29.0.60.0). Median follow-up duration was 105 months (IQR, 41.182). The frequency of clinical stage I at pretreatment CT was 81% (1017 of 1257). The 10-year lung cancer.specific survival of 1257 participants was 81% (95% CI: 79, 84) and the 20-year lung cancer.specific survival was 81% (95% CI: 78, 83), and it was 95% (95% CI: 91, 98) for 181 participants with pathologic T1aN0M0 lung cancer. Conclusion: The 10-year lung cancer.specific survival of 80% reported in 2006 for I-ELCAP participants enrolled in annual low-dose CT screening and diagnosed with a first primary lung cancer has persisted, as shown by the updated 20-year lung cancer.specific survival for the expanded I-ELCAP cohort.
AB - Background: The low-dose CT (≤3 mGy) screening report of 1000 Early Lung Cancer Action Program (ELCAP) participants in 1999 led to the International ELCAP (I-ELCAP) collaboration, which enrolled 31 567 participants in annual low-dose CT screening between 1992 and 2005. In 2006, I-ELCAP investigators reported the 10-year lung cancer.specific survival of 80% for 484 participants diagnosed with a first primary lung cancer through annual screening, with a high frequency of clinical stage I lung cancer (85%). Purpose: To update the cure rate by determining the 20-year lung cancer.specific survival of participants diagnosed with first primary lung cancer through annual low-dose CT screening in the expanded I-ELCAP cohort. Materials and Methods: For participants enrolled in the HIPAA-compliant prospective I-ELCAP cohort between 1992 and 2022 and observed until December 30, 2022, Kaplan-Meier survival analysis was used to determine the 10- and 20-year lung cancer.specific survival of participants diagnosed with first primary lung cancer through annual low-dose CT screening. Eligible participants were aged at least 40 years and had current or former cigarette use or had never smoked but had been exposed to secondhand tobacco smoke. Results: Among 89 404 I-ELCAP participants, 1257 (1.4%) were diagnosed with a first primary lung cancer (684 male, 573 female; median age, 66 years; IQR, 61.72), with a median smoking history of 43.0 pack-years (IQR, 29.0.60.0). Median follow-up duration was 105 months (IQR, 41.182). The frequency of clinical stage I at pretreatment CT was 81% (1017 of 1257). The 10-year lung cancer.specific survival of 1257 participants was 81% (95% CI: 79, 84) and the 20-year lung cancer.specific survival was 81% (95% CI: 78, 83), and it was 95% (95% CI: 91, 98) for 181 participants with pathologic T1aN0M0 lung cancer. Conclusion: The 10-year lung cancer.specific survival of 80% reported in 2006 for I-ELCAP participants enrolled in annual low-dose CT screening and diagnosed with a first primary lung cancer has persisted, as shown by the updated 20-year lung cancer.specific survival for the expanded I-ELCAP cohort.
UR - http://www.scopus.com/inward/record.url?scp=85176352693&partnerID=8YFLogxK
U2 - 10.1148/radiol.231988
DO - 10.1148/radiol.231988
M3 - Article
C2 - 37934099
AN - SCOPUS:85176352693
SN - 0033-8419
VL - 309
JO - Radiology
JF - Radiology
IS - 2
M1 - e231988
ER -