7 Oxo Δ1 tetrahydrocannabinol: a novel metabolite of Δ1 tetrahydrocannabinol

Z. Ben Zvi, S. Burstein

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

A careful analysis of the incubation products of Δ9 tetrahydrocannabinol (THC) with rat liver microsomes revealed the presence of a hitherto unidentified metabolite. Mass spectral data suggested the 7 oxo derivative; LiAlH4 reduction of this product gave 7 hydroxy Δ9 tetrahydrocannabinol substantiating this assignment. Such an aldehyde is a likely intermediate in the detoxication of Δ9 THC which leads to acidic products.

Original languageEnglish
Pages (from-to)223-229
Number of pages7
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume8
Issue number2
StatePublished - 1974
Externally publishedYes

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