550 cases of prenatal cytogenetic diagnosis: Experience and prospects

L. Y.F. Hsu, F. Yahr, H. J. Kim, T. Kerenyi, K. Hirschhorn

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Since 1966, the technique of culturing amniotic fluid cells has been developed and improved. The cultivated amniotic fluid cells have been used for both cytogenetic and biochemical studies. Various genetically determined disorders can now be prenatally diagnosed; hence, birth of such affected children can be prevented. However, the greatest demand has always been for prenatal cytogenetic diagnosis. This paper reports the results of the first 568 cytogenetic cases collected in 6 years experience in prenatal diagnosis, 550 of which resulted in successful diagnosis.

Original languageEnglish
Pages (from-to)135-149
Number of pages15
JournalMount Sinai Journal of Medicine
Issue number1
StatePublished - 1978


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