TY - JOUR
T1 - 5' -Hydrogenphosphonates and 5' -methylphosphonates of sugar modified pyrimidine nucleosides as potential anti-hiv-1 agents
AU - Krayevsky, Alexander A.
AU - Chou, Ting Chao
AU - Baron, Penny
AU - Polsky, Bruce
AU - Jiang, Xiang Jun
AU - Matulič-Adamič, Jasenka
AU - Rosenberg, Ivan
AU - Watanabe, Kyoichi A.
N1 - Funding Information:
the National Institute of All- and Infectious Diseases and the National Cancer Institute, NIH, U.S.D.H.H.S. (Grants c1118601, CA08748 and AI26056) .
PY - 1992/2/1
Y1 - 1992/2/1
N2 - A number of nucleoside 5‘;-hydrogenphosphonates and nucleoside 5‘;-ioethylphosphonates were prepared, to study their ability to inhibit replication of HIV-1. Two compounds, the 5’-hydrogenphosphonate of 3’;-azido-3‘; -deoxythymidine (AZT-HP, IVc) and of 3‘; -deoxy-3‘; -fluorothymidine (FLT-HP, IVa), exhibit potent anti-HIV-1 activity with selectivity indices similar to or better than those of their parent nucleosides.
AB - A number of nucleoside 5‘;-hydrogenphosphonates and nucleoside 5‘;-ioethylphosphonates were prepared, to study their ability to inhibit replication of HIV-1. Two compounds, the 5’-hydrogenphosphonate of 3’;-azido-3‘; -deoxythymidine (AZT-HP, IVc) and of 3‘; -deoxy-3‘; -fluorothymidine (FLT-HP, IVa), exhibit potent anti-HIV-1 activity with selectivity indices similar to or better than those of their parent nucleosides.
UR - http://www.scopus.com/inward/record.url?scp=0026562842&partnerID=8YFLogxK
U2 - 10.1080/07328319208021696
DO - 10.1080/07328319208021696
M3 - Article
AN - SCOPUS:0026562842
SN - 0732-8311
VL - 11
SP - 177
EP - 196
JO - Nucleosides and Nucleotides
JF - Nucleosides and Nucleotides
IS - 2-4
ER -