5-HT1b, receptors in an animal model of depression

Emmeline Edwards; Kelly Harkins; G. Wright; F. A. Henn

doi:10.1016/0028-3908(91)90050-L

5-HT_1b, receptors in an animal model of depression

Emmeline Edwards, Kelly Harkins, G. Wright, F. A. Henn

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

After exposure to a 0.8 mA course of uncontrollable shocks, Sprague-Dawley rats can be differentiated into two distinct groups defined in term of their performance in a shock escape paradigm. Learned helpless (LH) rats do not learn to escape a controllable shock while non-helpless (NLH) rats learn this response as quickly as naive controls (NC) rats do. The current experiments were designed to extend our studies of 5-HT receptors in these three groups of rats. The major finding in the present study concerned post-synaptic 5-HI receptor effects in the cortex, hippocampus, septum and hypothalamus of LH rats. These included an up regulation of 5-HT_1b receptors in the cortex, hippocampus and septum in LH rats. In contrast, 5-HT_1b receptors in the hypothalamus of LH rats were down-regulated. These results implicate serotonergic mechanisms in the behavioral deficit caused by uncontrollable shock with a limbic-hypothalamic circuit serving as a center for adaptation to stress.

Original language	English
Pages (from-to)	101-105
Number of pages	5
Journal	Neuropharmacology
Volume	30
Issue number	1
DOIs	https://doi.org/10.1016/0028-3908(91)90050-L
State	Published - Jan 1991
Externally published	Yes

Keywords

5-HT binding sites
5-HT binding sites
5-hydroxytryptamine (5-HT)
Learned helplessness
depression
serotonin receptor
stress

Access to Document

10.1016/0028-3908(91)90050-L

Cite this

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title = "5-HT1b, receptors in an animal model of depression",

abstract = "After exposure to a 0.8 mA course of uncontrollable shocks, Sprague-Dawley rats can be differentiated into two distinct groups defined in term of their performance in a shock escape paradigm. Learned helpless (LH) rats do not learn to escape a controllable shock while non-helpless (NLH) rats learn this response as quickly as naive controls (NC) rats do. The current experiments were designed to extend our studies of 5-HT receptors in these three groups of rats. The major finding in the present study concerned post-synaptic 5-HI receptor effects in the cortex, hippocampus, septum and hypothalamus of LH rats. These included an up regulation of 5-HT1b receptors in the cortex, hippocampus and septum in LH rats. In contrast, 5-HT1b receptors in the hypothalamus of LH rats were down-regulated. These results implicate serotonergic mechanisms in the behavioral deficit caused by uncontrollable shock with a limbic-hypothalamic circuit serving as a center for adaptation to stress.",

keywords = "5-HT binding sites, 5-HT binding sites, 5-hydroxytryptamine (5-HT), Learned helplessness, depression, serotonin receptor, stress",

author = "Emmeline Edwards and Kelly Harkins and G. Wright and Henn, {F. A.}",

note = "Funding Information: This research was supported by a National Science Foundation grant: BNS - 8614098 to E.Fdwards and a Bristol-Myers grant to F.A. Henn. We wish to thank Randolph Rosarion for technical assistance and Judy Shivak for typing the manuscript.",

year = "1991",

month = jan,

doi = "10.1016/0028-3908(91)90050-L",

language = "English",

volume = "30",

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journal = "Neuropharmacology",

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T1 - 5-HT1b, receptors in an animal model of depression

AU - Edwards, Emmeline

AU - Harkins, Kelly

AU - Wright, G.

AU - Henn, F. A.

N1 - Funding Information: This research was supported by a National Science Foundation grant: BNS - 8614098 to E.Fdwards and a Bristol-Myers grant to F.A. Henn. We wish to thank Randolph Rosarion for technical assistance and Judy Shivak for typing the manuscript.

PY - 1991/1

Y1 - 1991/1

N2 - After exposure to a 0.8 mA course of uncontrollable shocks, Sprague-Dawley rats can be differentiated into two distinct groups defined in term of their performance in a shock escape paradigm. Learned helpless (LH) rats do not learn to escape a controllable shock while non-helpless (NLH) rats learn this response as quickly as naive controls (NC) rats do. The current experiments were designed to extend our studies of 5-HT receptors in these three groups of rats. The major finding in the present study concerned post-synaptic 5-HI receptor effects in the cortex, hippocampus, septum and hypothalamus of LH rats. These included an up regulation of 5-HT1b receptors in the cortex, hippocampus and septum in LH rats. In contrast, 5-HT1b receptors in the hypothalamus of LH rats were down-regulated. These results implicate serotonergic mechanisms in the behavioral deficit caused by uncontrollable shock with a limbic-hypothalamic circuit serving as a center for adaptation to stress.

AB - After exposure to a 0.8 mA course of uncontrollable shocks, Sprague-Dawley rats can be differentiated into two distinct groups defined in term of their performance in a shock escape paradigm. Learned helpless (LH) rats do not learn to escape a controllable shock while non-helpless (NLH) rats learn this response as quickly as naive controls (NC) rats do. The current experiments were designed to extend our studies of 5-HT receptors in these three groups of rats. The major finding in the present study concerned post-synaptic 5-HI receptor effects in the cortex, hippocampus, septum and hypothalamus of LH rats. These included an up regulation of 5-HT1b receptors in the cortex, hippocampus and septum in LH rats. In contrast, 5-HT1b receptors in the hypothalamus of LH rats were down-regulated. These results implicate serotonergic mechanisms in the behavioral deficit caused by uncontrollable shock with a limbic-hypothalamic circuit serving as a center for adaptation to stress.

KW - 5-HT binding sites

KW - 5-hydroxytryptamine (5-HT)

KW - Learned helplessness

KW - depression

KW - serotonin receptor

KW - stress

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