5-HT1b, receptors in an animal model of depression

Emmeline Edwards, Kelly Harkins, G. Wright, F. A. Henn

Research output: Contribution to journalArticlepeer-review

57 Scopus citations


After exposure to a 0.8 mA course of uncontrollable shocks, Sprague-Dawley rats can be differentiated into two distinct groups defined in term of their performance in a shock escape paradigm. Learned helpless (LH) rats do not learn to escape a controllable shock while non-helpless (NLH) rats learn this response as quickly as naive controls (NC) rats do. The current experiments were designed to extend our studies of 5-HT receptors in these three groups of rats. The major finding in the present study concerned post-synaptic 5-HI receptor effects in the cortex, hippocampus, septum and hypothalamus of LH rats. These included an up regulation of 5-HT1b receptors in the cortex, hippocampus and septum in LH rats. In contrast, 5-HT1b receptors in the hypothalamus of LH rats were down-regulated. These results implicate serotonergic mechanisms in the behavioral deficit caused by uncontrollable shock with a limbic-hypothalamic circuit serving as a center for adaptation to stress.

Original languageEnglish
Pages (from-to)101-105
Number of pages5
Issue number1
StatePublished - Jan 1991
Externally publishedYes


  • 5-HT binding sites
  • 5-HT binding sites
  • 5-hydroxytryptamine (5-HT)
  • Learned helplessness
  • depression
  • serotonin receptor
  • stress


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