3D PIB and CSF biomarker associations with hippocampal atrophy in ADNI subjects

Liana G. Apostolova; Kristy S. Hwang; John P. Andrawis; Amity E. Green; Sona Babakchanian; Jonathan H. Morra; Jeffrey L. Cummings; Arthur W. Toga; John Q. Trojanowski; Leslie M. Shaw; Clifford R. Jack; Ronald C. Petersen; Paul S. Aisen; William J. Jagust; Robert A. Koeppe; Chester A. Mathis; Michael W. Weiner; Paul M. Thompson

doi:10.1016/j.neurobiolaging.2010.05.003

3D PIB and CSF biomarker associations with hippocampal atrophy in ADNI subjects

Liana G. Apostolova, Kristy S. Hwang, John P. Andrawis, Amity E. Green, Sona Babakchanian, Jonathan H. Morra, Jeffrey L. Cummings, Arthur W. Toga, John Q. Trojanowski, Leslie M. Shaw, Clifford R. Jack, Ronald C. Petersen, Paul S. Aisen, William J. Jagust, Robert A. Koeppe, Chester A. Mathis, Michael W. Weiner, Paul M. Thompson

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127 Scopus citations

Abstract

Cerebrospinal fluid (CSF) measures of Ab and tau, Pittsburgh Compound B (PIB) imaging and hippocampal atrophy are promising Alzheimer's disease biomarkers yet the associations between them are not known. We applied a validated, automated hippocampal labeling method and 3D radial distance mapping to the 1.5T structural magnetic resonance imaging (MRI) data of 388 ADNI subjects with baseline CSF Ab₄₂, total tau (t-tau) and phosphorylated tau (p-tau₁₈₁) and 98 subjects with positron emission tomography (PET) imaging using PIB. We used linear regression to investigate associations between hippocampal atrophy and average cortical, parietal and precuneal PIB standardized uptake value ratio (SUVR) and CSF Ab₄₂, t-tau, p-tau₁₈₁, t-tau/Ab₄₂ and p-tau₁₈₁/Ab₄₂. All CSF measures showed significant associations with hippocampal volume and radial distance in the pooled sample. Strongest correlations were seen for p-tau₁₈₁, followed by p-tau₁₈₁/Ab₄₂ ratio, t-tau/Ab₄₂ ratio, t-tau and Ab₄₂. p-tau₁₈₁ showed stronger correlation in ApoE4 carriers, while t-tau showed stronger correlation in ApoE4 noncarriers. Of the 3 PIB measures the precuneal SUVR showed strongest associations with hippocampal atrophy.

Original language	English
Pages (from-to)	1284-1303
Number of pages	20
Journal	Neurobiology of Aging
Volume	31
Issue number	8
DOIs	https://doi.org/10.1016/j.neurobiolaging.2010.05.003
State	Published - Aug 2010
Externally published	Yes

Keywords

ADNI
Abeta
Alzheimer's disease
Amyloid imaging
Atrophy
Biomarkers
Hippocampus
Imaging
MRI
Magnetic resonance imaging
PIB
Tau

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10.1016/j.neurobiolaging.2010.05.003

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Apostolova, L. G., Hwang, K. S., Andrawis, J. P., Green, A. E., Babakchanian, S., Morra, J. H., Cummings, J. L., Toga, A. W., Trojanowski, J. Q., Shaw, L. M., Jack, C. R., Petersen, R. C., Aisen, P. S., Jagust, W. J., Koeppe, R. A., Mathis, C. A., Weiner, M. W., & Thompson, P. M. (2010). 3D PIB and CSF biomarker associations with hippocampal atrophy in ADNI subjects. Neurobiology of Aging, 31(8), 1284-1303. https://doi.org/10.1016/j.neurobiolaging.2010.05.003

@article{d272f286a6d14627a8170abb04ec7bb9,

title = "3D PIB and CSF biomarker associations with hippocampal atrophy in ADNI subjects",

abstract = "Cerebrospinal fluid (CSF) measures of Ab and tau, Pittsburgh Compound B (PIB) imaging and hippocampal atrophy are promising Alzheimer's disease biomarkers yet the associations between them are not known. We applied a validated, automated hippocampal labeling method and 3D radial distance mapping to the 1.5T structural magnetic resonance imaging (MRI) data of 388 ADNI subjects with baseline CSF Ab42, total tau (t-tau) and phosphorylated tau (p-tau181) and 98 subjects with positron emission tomography (PET) imaging using PIB. We used linear regression to investigate associations between hippocampal atrophy and average cortical, parietal and precuneal PIB standardized uptake value ratio (SUVR) and CSF Ab42, t-tau, p-tau181, t-tau/Ab42 and p-tau181/Ab42. All CSF measures showed significant associations with hippocampal volume and radial distance in the pooled sample. Strongest correlations were seen for p-tau181, followed by p-tau181/Ab42 ratio, t-tau/Ab42 ratio, t-tau and Ab42. p-tau181 showed stronger correlation in ApoE4 carriers, while t-tau showed stronger correlation in ApoE4 noncarriers. Of the 3 PIB measures the precuneal SUVR showed strongest associations with hippocampal atrophy.",

keywords = "ADNI, Abeta, Alzheimer's disease, Amyloid imaging, Atrophy, Biomarkers, Hippocampus, Imaging, MRI, Magnetic resonance imaging, PIB, Tau",

author = "Apostolova, {Liana G.} and Hwang, {Kristy S.} and Andrawis, {John P.} and Green, {Amity E.} and Sona Babakchanian and Morra, {Jonathan H.} and Cummings, {Jeffrey L.} and Toga, {Arthur W.} and Trojanowski, {John Q.} and Shaw, {Leslie M.} and Jack, {Clifford R.} and Petersen, {Ronald C.} and Aisen, {Paul S.} and Jagust, {William J.} and Koeppe, {Robert A.} and Mathis, {Chester A.} and Weiner, {Michael W.} and Thompson, {Paul M.}",

note = "Funding Information: The analyses reported in this manuscript were funded by the Easton Consortium for Alzheimer's Drug Discovery and Biomarker Development (to LGA, NIA K23 AG026803 ; jointly sponsored by NIA , Afar , The John A. Hartford Foundation , The Atlantic Philanthropies , the Starr Foundation and an anonymous donor; to LGA), the Turken Foundation (to LGA); NIA P50 AG16570 (to JLC, LGAm and PMT); NIBIB EB01651 , NLM LM05639 , NCRR RR019771 (to PMT); and NIMH R01 MH071940 , NCRR P41 RR013642 , and NIH U54 RR021813 (to AWT). JPA involvement was supported by NIA T35 AG026736 .",

year = "2010",

month = aug,

doi = "10.1016/j.neurobiolaging.2010.05.003",

language = "English",

volume = "31",

pages = "1284--1303",

journal = "Neurobiology of Aging",

issn = "0197-4580",

publisher = "Elsevier Inc.",

number = "8",

}

Apostolova, LG, Hwang, KS, Andrawis, JP, Green, AE, Babakchanian, S, Morra, JH, Cummings, JL, Toga, AW, Trojanowski, JQ, Shaw, LM, Jack, CR, Petersen, RC, Aisen, PS, Jagust, WJ, Koeppe, RA, Mathis, CA, Weiner, MW & Thompson, PM 2010, '3D PIB and CSF biomarker associations with hippocampal atrophy in ADNI subjects', Neurobiology of Aging, vol. 31, no. 8, pp. 1284-1303. https://doi.org/10.1016/j.neurobiolaging.2010.05.003

TY - JOUR

T1 - 3D PIB and CSF biomarker associations with hippocampal atrophy in ADNI subjects

AU - Apostolova, Liana G.

AU - Hwang, Kristy S.

AU - Andrawis, John P.

AU - Green, Amity E.

AU - Babakchanian, Sona

AU - Morra, Jonathan H.

AU - Cummings, Jeffrey L.

AU - Toga, Arthur W.

AU - Trojanowski, John Q.

AU - Shaw, Leslie M.

AU - Jack, Clifford R.

AU - Petersen, Ronald C.

AU - Aisen, Paul S.

AU - Jagust, William J.

AU - Koeppe, Robert A.

AU - Mathis, Chester A.

AU - Weiner, Michael W.

AU - Thompson, Paul M.

N1 - Funding Information: The analyses reported in this manuscript were funded by the Easton Consortium for Alzheimer's Drug Discovery and Biomarker Development (to LGA, NIA K23 AG026803 ; jointly sponsored by NIA , Afar , The John A. Hartford Foundation , The Atlantic Philanthropies , the Starr Foundation and an anonymous donor; to LGA), the Turken Foundation (to LGA); NIA P50 AG16570 (to JLC, LGAm and PMT); NIBIB EB01651 , NLM LM05639 , NCRR RR019771 (to PMT); and NIMH R01 MH071940 , NCRR P41 RR013642 , and NIH U54 RR021813 (to AWT). JPA involvement was supported by NIA T35 AG026736 .

PY - 2010/8

Y1 - 2010/8

N2 - Cerebrospinal fluid (CSF) measures of Ab and tau, Pittsburgh Compound B (PIB) imaging and hippocampal atrophy are promising Alzheimer's disease biomarkers yet the associations between them are not known. We applied a validated, automated hippocampal labeling method and 3D radial distance mapping to the 1.5T structural magnetic resonance imaging (MRI) data of 388 ADNI subjects with baseline CSF Ab42, total tau (t-tau) and phosphorylated tau (p-tau181) and 98 subjects with positron emission tomography (PET) imaging using PIB. We used linear regression to investigate associations between hippocampal atrophy and average cortical, parietal and precuneal PIB standardized uptake value ratio (SUVR) and CSF Ab42, t-tau, p-tau181, t-tau/Ab42 and p-tau181/Ab42. All CSF measures showed significant associations with hippocampal volume and radial distance in the pooled sample. Strongest correlations were seen for p-tau181, followed by p-tau181/Ab42 ratio, t-tau/Ab42 ratio, t-tau and Ab42. p-tau181 showed stronger correlation in ApoE4 carriers, while t-tau showed stronger correlation in ApoE4 noncarriers. Of the 3 PIB measures the precuneal SUVR showed strongest associations with hippocampal atrophy.

AB - Cerebrospinal fluid (CSF) measures of Ab and tau, Pittsburgh Compound B (PIB) imaging and hippocampal atrophy are promising Alzheimer's disease biomarkers yet the associations between them are not known. We applied a validated, automated hippocampal labeling method and 3D radial distance mapping to the 1.5T structural magnetic resonance imaging (MRI) data of 388 ADNI subjects with baseline CSF Ab42, total tau (t-tau) and phosphorylated tau (p-tau181) and 98 subjects with positron emission tomography (PET) imaging using PIB. We used linear regression to investigate associations between hippocampal atrophy and average cortical, parietal and precuneal PIB standardized uptake value ratio (SUVR) and CSF Ab42, t-tau, p-tau181, t-tau/Ab42 and p-tau181/Ab42. All CSF measures showed significant associations with hippocampal volume and radial distance in the pooled sample. Strongest correlations were seen for p-tau181, followed by p-tau181/Ab42 ratio, t-tau/Ab42 ratio, t-tau and Ab42. p-tau181 showed stronger correlation in ApoE4 carriers, while t-tau showed stronger correlation in ApoE4 noncarriers. Of the 3 PIB measures the precuneal SUVR showed strongest associations with hippocampal atrophy.

KW - ADNI

KW - Abeta

KW - Alzheimer's disease

KW - Amyloid imaging

KW - Atrophy

KW - Biomarkers

KW - Hippocampus

KW - Imaging

KW - MRI

KW - Magnetic resonance imaging

KW - PIB

KW - Tau

UR - http://www.scopus.com/inward/record.url?scp=77954033982&partnerID=8YFLogxK

U2 - 10.1016/j.neurobiolaging.2010.05.003

DO - 10.1016/j.neurobiolaging.2010.05.003

M3 - Article

C2 - 20538372

AN - SCOPUS:77954033982

SN - 0197-4580

VL - 31

SP - 1284

EP - 1303

JO - Neurobiology of Aging

JF - Neurobiology of Aging

IS - 8

ER -

3D PIB and CSF biomarker associations with hippocampal atrophy in ADNI subjects

Abstract

Keywords

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