3D mapping of language networks in clinical and pre-clinical Alzheimer's disease

Liana G. Apostolova, Po Lu, Steve Rogers, Rebecca A. Dutton, Kiralee M. Hayashi, Arthur W. Toga, Jeffrey L. Cummings, Paul M. Thompson

Research output: Contribution to journalArticlepeer-review

55 Scopus citations

Abstract

We investigated the associations between Boston naming and the animal fluency tests and cortical atrophy in 19 probable AD and 5 multiple domain amnestic mild cognitive impairment patients who later converted to AD. We applied a surface-based computational anatomy technique to MRI scans of the brain and then used linear regression models to detect associations between animal fluency and Boston Naming Test (BNT) performance and cortical atrophy. The global permutation-corrected significance for the maps associating BNT performance with cortical atrophy was p = .0124 for the left and p = .0196 for the right hemisphere and for the animal fluency maps p = .055 for the left and p = .073 for the right hemisphere. The degree of language impairment correlated with cortical atrophy in the left temporal and parietal lobes (BA 20, 21, 37, 39, 40, and 7), bilateral frontal lobes (BA 8, 9, and 44) and the right temporal pole (BA 38). Using a novel 3D mapping technique, we demonstrated that in AD language abilities are strongly influenced by the integrity of the perisylvian cortical regions.

Original languageEnglish
Pages (from-to)33-41
Number of pages9
JournalBrain and Language
Volume104
Issue number1
DOIs
StatePublished - Jan 2008
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Animal fluency
  • Boston Naming Test
  • Brain atrophy
  • Cortical atrophy
  • Gray matter atrophy
  • Language
  • Mild cognitive impairment

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