TY - GEN
T1 - 3D engineered patient-derived xenograft tumors to recapitulate the obese colorectal cancer tumor microenvironment
AU - Hassani, Iman
AU - Anbiah, Benjamin
AU - Ahmed, Bulbul
AU - Habbit, Nicole L.
AU - Greene, Michael W.
AU - Lipke, Elizabeth A.
N1 - Publisher Copyright:
© 2019 Omnipress - All rights reserved.
PY - 2019
Y1 - 2019
N2 - Statement of Purpose: Colorectal cancer (CRC) remains the third most prevalent cancer and cause of cancer-related deaths among both men and women in the United States. Consistent evidence from epidemiological studies indicates that obesity is associated with greater risk of CRC. However, the precise molecular mechanisms by which obesity favors the occurrence of neoplastic and malignant transformation have not been fully elucidated, in part because relevant experimental models are lacking. In this study, we have established an in vitro model of the obese, insulin resistant tumor microenvironment using patient-derived xenograft (PDX) CRC cells and investigated the ability of our model to recapitulate an in vivo obese model of orthotopically implanted PDX CRC.
AB - Statement of Purpose: Colorectal cancer (CRC) remains the third most prevalent cancer and cause of cancer-related deaths among both men and women in the United States. Consistent evidence from epidemiological studies indicates that obesity is associated with greater risk of CRC. However, the precise molecular mechanisms by which obesity favors the occurrence of neoplastic and malignant transformation have not been fully elucidated, in part because relevant experimental models are lacking. In this study, we have established an in vitro model of the obese, insulin resistant tumor microenvironment using patient-derived xenograft (PDX) CRC cells and investigated the ability of our model to recapitulate an in vivo obese model of orthotopically implanted PDX CRC.
UR - https://www.scopus.com/pages/publications/85065388998
M3 - Conference contribution
AN - SCOPUS:85065388998
T3 - Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
SP - 410
BT - Society for Biomaterials Annual Meeting and Exposition 2019
PB - Society for Biomaterials
T2 - 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Y2 - 3 April 2019 through 6 April 2019
ER -