31P-Magnetic resonance spectroscopy and thyroid hormones in major depressive disorder: Toward a bioenergetic mechanism in depression?

Dan V. Iosifescu, Perry F. Renshaw

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations

Abstract

In this paper we review studies of brain cellular high-energy phosphate metabolism, as measured by phosphorus-31 magnetic resonance spectroscopy (31P-MRS), in subjects with major depressive disorder (MDD). We also review the literature on the role of thyroid hormones on the cellular high-energy phosphate metabolism in multiple organs. Finally, we review data on the efficacy of thyroid hormones as adjuvant treatment in MDD. The framework established by these findings enables us to hypothesize that dysfunction of brain cellular energy metabolism is a vulnerability factor for MDD, and that correcting cellular energy metabolism (e.g., with thyroid hormones) is a valid therapeutic strategy for improving the symptoms of MDD. We discuss our hypothesis in the context of other current theories on the mechanism of thyroid hormones in MDD.

Original languageEnglish
Pages (from-to)51-63
Number of pages13
JournalHarvard Review of Psychiatry
Volume11
Issue number2
DOIs
StatePublished - Mar 2003
Externally publishedYes

Fingerprint

Dive into the research topics of '31P-Magnetic resonance spectroscopy and thyroid hormones in major depressive disorder: Toward a bioenergetic mechanism in depression?'. Together they form a unique fingerprint.

Cite this