@article{aa5f7987d63243cea831f4fcbcc539e4,
title = "2-deoxy-2-[18F]fluoro-d-mannose positron emission tomography imaging in atherosclerosis",
abstract = "Progressive inflammation in atherosclerotic plaques is associated with increasing risk of plaque rupture. Molecular imaging of activated macrophages with 2-deoxy-2-[ 18 F]fluoro-D-glucose ([ 18 F]FDG) has been proposed for identification of patients at higher risk for acute vascular events. Because mannose is an isomer of glucose that is taken up by macrophages through glucose transporters and because mannose receptors are expressed on a subset of the macrophage population in high-risk plaques, we applied 18 F-labeled mannose (2-deoxy-2-[18 F]fluoro-D-mannose, [ 18 F]FDM) for targeting of plaque inflammation. Here, we describe comparable uptake of [ 18 F]FDM and [18F]FDG in atherosclerotic lesions in a rabbit model; [ 18 F]FDM uptake was proportional to the plaque macrophage population. Our FDM competition studies in cultured cells with 2-deoxy-2-[14C]carbon-D-glucose ([14C]2DG) support at least 35% higher [18F]FDM uptake by macrophages in cell experiments. We also demonstrate that FDM restricts binding of anti-mannose receptor antibody to macrophages by approximately 35% and that mannose receptor targeting may provide an additional avenue for imaging of plaque inflammation.",
author = "Nobuhiro Tahara and Jogeshwar Mukherjee and {De Haas}, {Hans J.} and Petrov, {Artiom D.} and Ahmed Tawakol and Nezam Haider and Atsuko Tahara and Constantinescu, {Cristian C.} and Jun Zhou and Boersma, {Hendrikus H.} and Tsutomu Imaizumi and Masataka Nakano and Aloke Finn and Zahi Fayad and Renu Virmani and Valentin Fuster and Lisardo Bosca and Jagat Narula",
note = "Funding Information: We thank E. Lopez-Collazo for help in the preparation of human macrophages. Additionally, we thank T. Yamaki, D.S. Mohar, S. Pandey, M. Pan, R. Kant and R. Coleman for their help in development of tracer labeling and [18F]FDM imaging. Finally, we thank C. Minh and J. Song for their valuable help with analyzing PET images. This research was supported by a research grant from the International Research Fund for Subsidy of Kyusyu University School of Medicine Alumni and the Banyu Fellowship Program sponsored by Banyu Life Science Foundation International to N.T., research grants from the foundation De Drie Lichten and the Dutch Heart Association (Dr. E. Dekker student grant) to H.J.d.H., grants BFU2011-24760 and RD12/0042/0019 from the Spanish Government to L.B., US National Institutes of Health grant S10RR019269 from the US National Center for Research Resources and grant R01 EB006110 from the US National Institute of Biomedical Imaging and Bioengineering to J.M. and US National Institutes of Health grant 1RO1-HL68657 to J.N.",
year = "2014",
month = feb,
doi = "10.1038/nm.3437",
language = "English",
volume = "20",
pages = "215--219",
journal = "Nature Medicine",
issn = "1078-8956",
publisher = "Nature Publishing Group",
number = "2",
}