Abstract
Biaryl amides were discovered as novel and subtype selective M1 muscarinic acetylcholine receptor agonists. The identification, synthesis, and initial structure-activity relationships that led to compounds 3j and 4c, possessing good M1 agonist potency and intrinsic activity, and subtype selectivity for M1 over M2-5, are described.
Original language | English |
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Pages (from-to) | 3540-3544 |
Number of pages | 5 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 20 |
Issue number | 12 |
DOIs | |
State | Published - 2010 |
Externally published | Yes |
Keywords
- 2′ Biaryl amides
- Novel M1 agonists
- Subtype selective M1 muscarinic acetylcholine receptor agonist