2-{3-[2-(4-Chlorophenyl)ethoxy]-phenylthio}-2-methylpropanoic acid: A fibrate-like compound with hypolipidemic and antidiabetic activity

Natalina Dell'Uomo; Emanuela Tassoni; Tiziana Brunetti; Pompeo Pessotto; Anna F. Sciarroni; Ferdinando M. Milazzo; Francesco De Angelis; Alessandro Peschechera; Maria O. Tinti; Paolo Carminati; Fabio Giannessi

doi:10.1002/cmdc.200500007

2-{3-[2-(4-Chlorophenyl)ethoxy]-phenylthio}-2-methylpropanoic acid: A fibrate-like compound with hypolipidemic and antidiabetic activity

Natalina Dell'Uomo
, Emanuela Tassoni
, Tiziana Brunetti
, Pompeo Pessotto
, Anna F. Sciarroni
, Ferdinando M. Milazzo
, Francesco De Angelis
, Alessandro Peschechera
, Maria O. Tinti
, Paolo Carminati
, Fabio Giannessi

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Combating diabetes: The new fibrate-like compounds 1 were synthesized and showed antidiabetic and hypolipidemic activities in diabetic mice and in models of hyperlipidemia and PPARα activation. The acid form is an especially promising candidate for further investigation and preclinical development as a hypolipidemic and insulin-sensitizing agent.

Original language	English
Pages (from-to)	49-53
Number of pages	5
Journal	ChemMedChem
Volume	1
Issue number	1
DOIs	https://doi.org/10.1002/cmdc.200500007
State	Published - Jan 2006
Externally published	Yes

Keywords

Antidiabetics
Biological activity
Hypolipidemics
Medicinal chemistry
PPAR

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10.1002/cmdc.200500007

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Dell'Uomo, N., Tassoni, E., Brunetti, T., Pessotto, P., Sciarroni, A. F., Milazzo, F. M., De Angelis, F., Peschechera, A., Tinti, M. O., Carminati, P., & Giannessi, F. (2006). 2-{3-[2-(4-Chlorophenyl)ethoxy]-phenylthio}-2-methylpropanoic acid: A fibrate-like compound with hypolipidemic and antidiabetic activity. ChemMedChem, 1(1), 49-53. https://doi.org/10.1002/cmdc.200500007

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title = "2-\{3-[2-(4-Chlorophenyl)ethoxy]-phenylthio\}-2-methylpropanoic acid: A fibrate-like compound with hypolipidemic and antidiabetic activity",

abstract = "Combating diabetes: The new fibrate-like compounds 1 were synthesized and showed antidiabetic and hypolipidemic activities in diabetic mice and in models of hyperlipidemia and PPARα activation. The acid form is an especially promising candidate for further investigation and preclinical development as a hypolipidemic and insulin-sensitizing agent.",

keywords = "Antidiabetics, Biological activity, Hypolipidemics, Medicinal chemistry, PPAR",

author = "Natalina Dell'Uomo and Emanuela Tassoni and Tiziana Brunetti and Pompeo Pessotto and Sciarroni, \{Anna F.\} and Milazzo, \{Ferdinando M.\} and \{De Angelis\}, Francesco and Alessandro Peschechera and Tinti, \{Maria O.\} and Paolo Carminati and Fabio Giannessi",

year = "2006",

month = jan,

doi = "10.1002/cmdc.200500007",

language = "English",

volume = "1",

pages = "49--53",

journal = "ChemMedChem",

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Dell'Uomo, N, Tassoni, E, Brunetti, T, Pessotto, P, Sciarroni, AF, Milazzo, FM, De Angelis, F, Peschechera, A, Tinti, MO, Carminati, P & Giannessi, F 2006, '2-{3-[2-(4-Chlorophenyl)ethoxy]-phenylthio}-2-methylpropanoic acid: A fibrate-like compound with hypolipidemic and antidiabetic activity', ChemMedChem, vol. 1, no. 1, pp. 49-53. https://doi.org/10.1002/cmdc.200500007

TY - JOUR

T1 - 2-{3-[2-(4-Chlorophenyl)ethoxy]-phenylthio}-2-methylpropanoic acid

T2 - A fibrate-like compound with hypolipidemic and antidiabetic activity

AU - Dell'Uomo, Natalina

AU - Tassoni, Emanuela

AU - Brunetti, Tiziana

AU - Pessotto, Pompeo

AU - Sciarroni, Anna F.

AU - Milazzo, Ferdinando M.

AU - De Angelis, Francesco

AU - Peschechera, Alessandro

AU - Tinti, Maria O.

AU - Carminati, Paolo

AU - Giannessi, Fabio

PY - 2006/1

Y1 - 2006/1

N2 - Combating diabetes: The new fibrate-like compounds 1 were synthesized and showed antidiabetic and hypolipidemic activities in diabetic mice and in models of hyperlipidemia and PPARα activation. The acid form is an especially promising candidate for further investigation and preclinical development as a hypolipidemic and insulin-sensitizing agent.

AB - Combating diabetes: The new fibrate-like compounds 1 were synthesized and showed antidiabetic and hypolipidemic activities in diabetic mice and in models of hyperlipidemia and PPARα activation. The acid form is an especially promising candidate for further investigation and preclinical development as a hypolipidemic and insulin-sensitizing agent.

KW - Antidiabetics

KW - Biological activity

KW - Hypolipidemics

KW - Medicinal chemistry

KW - PPAR

UR - https://www.scopus.com/pages/publications/33746297651

U2 - 10.1002/cmdc.200500007

DO - 10.1002/cmdc.200500007

M3 - Article

C2 - 16892334

AN - SCOPUS:33746297651

SN - 1860-7179

VL - 1

SP - 49

EP - 53

JO - ChemMedChem

JF - ChemMedChem

IS - 1

ER -

2-{3-[2-(4-Chlorophenyl)ethoxy]-phenylthio}-2-methylpropanoic acid: A fibrate-like compound with hypolipidemic and antidiabetic activity

Abstract

Keywords

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