TY - JOUR
T1 - 15 year fulminant hepatitis B follow-up in Belgium
T2 - Viral evolution and signature of demographic change
AU - Mina, Thomas
AU - Amini-Bavil-Olyaee, Samad
AU - Shirvani-Dastgerdi, Elham
AU - Trovão, Nídia Sequeira
AU - Van Ranst, Marc
AU - Pourkarim, Mahmoud Reza
N1 - Funding Information:
Nídia Sequeira Trovão (NST) has received funding from the European Union Seventh Framework Programme [FP7/2007-2013] under Grant Agreement n° 278433-PREDEMICS and ERC Grant Agreement n° 260864.
Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2017/4/1
Y1 - 2017/4/1
N2 - Fulminant hepatitis among different clinical outcomes of hepatitis B virus infection is very rare and manifests high mortality rate, however it has not been investigated in Belgian inhabitants yet. In the frame of a retrospective study between 1995 and 2010, 80 serum samples (in some cases serial samples) archived in Biobank, were collected from 24 patients who had clinically developed fulminant infection of hepatitis B virus. In total, 33 hepatitis B virus (HBV) strains (31 full-length genome and 2 partial viral genes) of different HBV genotypes and subgenotypes including A2, B2, D1, D2, D3 and E, were amplified, sequenced and phylogenetically analyzed. HBV isolated strains from native and exotic patients were characterized by genome variations associated with viral invasiveness. Although several mutations at nucleotide and protein levels were detected, evolutionary analyses revealed a negative selective pressure over the viral genomes. This study revealed influence of immigration through a steady change in the viral epidemiological profile of the Belgian population.
AB - Fulminant hepatitis among different clinical outcomes of hepatitis B virus infection is very rare and manifests high mortality rate, however it has not been investigated in Belgian inhabitants yet. In the frame of a retrospective study between 1995 and 2010, 80 serum samples (in some cases serial samples) archived in Biobank, were collected from 24 patients who had clinically developed fulminant infection of hepatitis B virus. In total, 33 hepatitis B virus (HBV) strains (31 full-length genome and 2 partial viral genes) of different HBV genotypes and subgenotypes including A2, B2, D1, D2, D3 and E, were amplified, sequenced and phylogenetically analyzed. HBV isolated strains from native and exotic patients were characterized by genome variations associated with viral invasiveness. Although several mutations at nucleotide and protein levels were detected, evolutionary analyses revealed a negative selective pressure over the viral genomes. This study revealed influence of immigration through a steady change in the viral epidemiological profile of the Belgian population.
KW - Belgium
KW - Fulminant hepatitis B infection
KW - Immigrant
KW - Viral evolution
UR - http://www.scopus.com/inward/record.url?scp=85010807444&partnerID=8YFLogxK
U2 - 10.1016/j.meegid.2017.01.020
DO - 10.1016/j.meegid.2017.01.020
M3 - Article
C2 - 28119028
AN - SCOPUS:85010807444
VL - 49
SP - 221
EP - 225
JO - Infection, Genetics and Evolution
JF - Infection, Genetics and Evolution
SN - 1567-1348
ER -