1,3-Diaminopropan-2-ol Sulfonamides as potent and selective inhibitors of the glycine transporter type 1

Shahzad S. Rahman; Steven Coulton; Hugh J. Herdon; Graham F. Joiner; Jian Jin; Roderick A. Porter

doi:10.1016/j.bmcl.2006.12.063

1,3-Diaminopropan-2-ol Sulfonamides as potent and selective inhibitors of the glycine transporter type 1

Shahzad S. Rahman
, Steven Coulton
, Hugh J. Herdon
, Graham F. Joiner
, Jian Jin
, Roderick A. Porter

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

High throughput screening led to the discovery of a novel series of 1,3-diaminopropan-2-ol sulfonamides as selective GlyT-1 inhibitors. Structure-activity relationships of this novel series and optimisation of the initial hit that led to the identification of (2), a potent and selective GlyT-1 inhibitor, are also presented.

Original language	English
Pages (from-to)	1741-1745
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	17
Issue number	6
DOIs	https://doi.org/10.1016/j.bmcl.2006.12.063
State	Published - 15 Mar 2007
Externally published	Yes

Keywords

1,3-Diaminopropan-2-ol
GlyT-1
NMDA
Schizophrenia
Transporter

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10.1016/j.bmcl.2006.12.063

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title = "1,3-Diaminopropan-2-ol Sulfonamides as potent and selective inhibitors of the glycine transporter type 1",

abstract = "High throughput screening led to the discovery of a novel series of 1,3-diaminopropan-2-ol sulfonamides as selective GlyT-1 inhibitors. Structure-activity relationships of this novel series and optimisation of the initial hit that led to the identification of (2), a potent and selective GlyT-1 inhibitor, are also presented.",

keywords = "1,3-Diaminopropan-2-ol, GlyT-1, NMDA, Schizophrenia, Transporter",

author = "Rahman, \{Shahzad S.\} and Steven Coulton and Herdon, \{Hugh J.\} and Joiner, \{Graham F.\} and Jian Jin and Porter, \{Roderick A.\}",

year = "2007",

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doi = "10.1016/j.bmcl.2006.12.063",

language = "English",

volume = "17",

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TY - JOUR

T1 - 1,3-Diaminopropan-2-ol Sulfonamides as potent and selective inhibitors of the glycine transporter type 1

AU - Rahman, Shahzad S.

AU - Coulton, Steven

AU - Herdon, Hugh J.

AU - Joiner, Graham F.

AU - Jin, Jian

AU - Porter, Roderick A.

PY - 2007/3/15

Y1 - 2007/3/15

N2 - High throughput screening led to the discovery of a novel series of 1,3-diaminopropan-2-ol sulfonamides as selective GlyT-1 inhibitors. Structure-activity relationships of this novel series and optimisation of the initial hit that led to the identification of (2), a potent and selective GlyT-1 inhibitor, are also presented.

AB - High throughput screening led to the discovery of a novel series of 1,3-diaminopropan-2-ol sulfonamides as selective GlyT-1 inhibitors. Structure-activity relationships of this novel series and optimisation of the initial hit that led to the identification of (2), a potent and selective GlyT-1 inhibitor, are also presented.

KW - 1,3-Diaminopropan-2-ol

KW - GlyT-1

KW - NMDA

KW - Schizophrenia

KW - Transporter

UR - https://www.scopus.com/pages/publications/33847063198

U2 - 10.1016/j.bmcl.2006.12.063

DO - 10.1016/j.bmcl.2006.12.063

M3 - Article

C2 - 17234406

AN - SCOPUS:33847063198

SN - 0960-894X

VL - 17

SP - 1741

EP - 1745

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 6

ER -

1,3-Diaminopropan-2-ol Sulfonamides as potent and selective inhibitors of the glycine transporter type 1

Abstract

Keywords

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