11q deletion in neuroblastoma: A review of biological and clinical implications

Vid Mlakar, Simona Jurkovic Mlakar, Gonzalo Lopez, John M. Maris, Marc Ansari, Fabienne Gumy-Pause

Research output: Contribution to journalReview articlepeer-review

63 Scopus citations

Abstract

Deletion of the long arm of chromosome 11 (11q deletion) is one of the most frequent events that occur during the development of aggressive neuroblastoma. Clinically, 11q deletion is associated with higher disease stage and decreased survival probability. During the last 25â years, extensive efforts have been invested to identify the precise frequency of 11q aberrations in neuroblastoma, the recurrently involved genes, and to understand the molecular mechanisms of 11q deletion, but definitive answers are still unclear. In this review, it is our intent to compile and review the evidence acquired to date on 11q deletion in neuroblastoma.

Original languageEnglish
Article number114
JournalMolecular Cancer
Volume16
Issue number1
DOIs
StatePublished - 29 Jun 2017
Externally publishedYes

Keywords

  • 11q deletion
  • Cancer
  • Development
  • MYCN amplification
  • Metastasis
  • Neuroblastoma
  • Review

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