100% Complete response rate in patients with cutaneous metastatic melanoma treated with intralesional interleukin (IL)-2, imiquimod, and topical retinoid combination therapy: Results of a case series

Vivian Y. Shi, Khiem Tran, Forum Patel, Jonathan Leventhal, Thomas Konia, Maxwell A. Fung, Reason Wilken, Miki Shirakawa Garcia, Sarah D. Fitzmaurice, Jayne Joo, Arta M. Monjazeb, Barbara A. Burrall, Brett King, Steve Martinez, Scott D. Christensen, Emanual Maverakis

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

Background Patients with cutaneous melanoma metastases have experienced excellent responses to intralesional interleukin (IL)-2. This has led to its recent inclusion into the US National Comprehensive Cancer Network guidelines for management of cutaneous melanoma metastases. Despite this, intralesional IL-2 has not been highlighted in the US literature nor have US physicians adopted it. Objective We sought to evaluate the effectiveness of intralesional IL-2 combined with topical imiquimod and retinoid for treatment of cutaneous metastatic melanoma. Methods A retrospective case series of 11 patients with cutaneous metastatic melanoma were treated with intralesional IL-2 combined with topical imiquimod and retinoid. Results A 100% complete local response rate with long-term follow-up (average of 24 months) was seen in all 11 patients treated with this proposed regimen. Biopsy specimens of treated sites confirmed absence of malignant cells. The most common treatment-related adverse event was rigors. Limitations Small number of patients, retrospective review of charts, and lack of a comparison group were limitations. Conclusion Intralesional IL-2 administered concomitantly with topical imiquimod and a retinoid cream is a promising therapeutic option for managing cutaneous melanoma metastases. The regimen was well tolerated and should be considered as a reasonable alternative to surgical excision.

Original languageEnglish
Pages (from-to)645-654
Number of pages10
JournalJournal of the American Academy of Dermatology
Volume73
Issue number4
DOIs
StatePublished - 1 Oct 2015
Externally publishedYes

Keywords

  • imiquimod
  • interleukin
  • intralesional
  • metastatic melanoma
  • pemphigus vulgaris
  • retinoid

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