Abstract
：Major depressive disorder (M D D) is a prevalent condition associated with substantial impairment and low remission rates. Traditional antidepressants demonstrate delayed effects, low cure rate, and inadequate therapeutic effectiveness for m a n aging treatment-resistant depression (T R D). Several studies have shown that ketamine, a non-selective N-methyl-D-aspartate receptor (N M D A R) antagonist, can produce rapid and sustained antidepressant effects. Ketamine has demonstrated efficacy for reducing suicidality in T R D patients. However, the pharmacological mechanism for ketamine's antidepressant effects remains incompletely understood. Previous research suggests that the antidepressant effects of ketamine may involve the monoaminergic, glutamatergic and dopaminergic systems. This paper provides an overview of the pharmacological mechanism for ketamine's antidepressant effects and discuss the potential directions for future research.
| Translated title of the contribution | Research progress on neurobiological mechanisms underlying antidepressant effect of ketamine |
|---|---|
| Original language | Chinese (Traditional) |
| Pages (from-to) | 1622-1627 |
| Number of pages | 6 |
| Journal | Chinese Pharmacological Bulletin |
| Volume | 40 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 2024 |
| Externally published | Yes |
Keywords
- antidepressant
- dopaminergic systems
- glutamatergic system
- monoaminergic system
- ：ketamine; depression