槲 皮 素 基于 内 质 网应 激 信 号 通路 调 节 动物机体 健 康 和疾 病 的 研 究进 展

The endoplasmic reticulum (ER) was the place where proteins and lipids are biosynthesized and where transmembrane proteins are folded. Both pathological and physiological situations may disturb the func⁃ tion of the ER, resulting in endoplasmic reticulum stress (ERS). However, prolonged and severe ERS can lead to autophagy and/or the induction of cell apoptosis. Several studies implicated ERS as a major factor con⁃ tributing to many diseases. Therefore, the modulation of ERS pathways has become a potential therapeutic tar⁃ get. Quercetin is a plant⁃derived secondary metabolite, which belongs to the flavonoids class which presents a range of beneficial effects. The finding of research in recent years, quercetin can decrease the body risk of cancer, liver and pancreas disease, cardiovascular disease, intestinal disease, and reduce organ/tissue damage by regulating ERS signaling, and maintain animal health. The present study mainly reviewed the action mecha⁃ nism and research progress of quercetin regulating the ERS in animals. The review is aimed to provide a refer⁃ ence for the further development and utilization of quercetin, and also provide a new perspective for animals in treatment of ERS related diseases.