β-Endorphin and Schizophrenia

Philip A. Berger, Stanley J. Watson, Huda Akil, Glen R. Elliott, Robert T. Rubin, Adolf Pfefferbaum, Kenneth L. Davis, Jack D. Barchas, Choh Hao Li

Research output: Contribution to journalArticlepeer-review

68 Scopus citations

Abstract

To study the effects of β-endorphin in chronic schizophrenia, nine male patients participated in a double-blind crossover comparison of a single intravenous 20-mg injection of β-endorphin and saline. Bolus injection of β-endorphin from an albumincoated syringe produced markedly higher plasma concentrations than did slow intravenous infusion from a non$albumincoated syringe. β-endorphin intravenously injected in nine patients produced a statistically significant increase in serum prolactin levels. In one patient, both 10 mg of morphine sulfate and 20 mg of β-endorphin produced similar increases in the alpha power of the EEG. In eight patients, β-endorphin administration was associated with a statistically significant but not clinically obvious improvement in schizophrenic symptoms.

Original languageEnglish
Pages (from-to)635-640
Number of pages6
JournalArchives of General Psychiatry
Volume37
Issue number6
DOIs
StatePublished - Jun 1980
Externally publishedYes

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