β-Catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis

Lizhu Lin; Li Cui; Wenlai Zhou; Daniel Dufort; Xiaoxue Zhang; Chen Leng Cai; Lei Bu; Lei Yang; Jody Martin; Rolf Kemler; Michael G. Rosenfeld; Ju Chen; Sylvia M. Evans

doi:10.1073/pnas.0700923104

β-Catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis

Lizhu Lin
, Li Cui
, Wenlai Zhou
, Daniel Dufort
, Xiaoxue Zhang
, Chen Leng Cai
, Lei Bu
, Lei Yang
, Jody Martin
, Rolf Kemler
, Michael G. Rosenfeld
, Ju Chen
, Sylvia M. Evans

Research output: Contribution to journal › Article › peer-review

228 Scopus citations

Abstract

Recent studies have demonstrated that the LIM homeodomain transcription factor Islet1 (Isl1) marks pluripotent cardiovascular progenitor cells and is required for proliferation, survival, and migration of recently defined second heart field progenitors. Factors that are upstream of Isl1 in cardiovascular progenitors have not yet been defined. Here we demonstrate that β-catenin is required for Isl1 expression in cardiac progenitors, directly regulating the Isl1 promoter. Ablation of β-catenin in Isl1-expressing progenitors disrupts multiple aspects of cardiogenesis, resulting in embryonic lethality at E13. β-Catenin is also required upstream of a number of genes required for pharyngeal arch, outflow tract, and/or atrial septal morphogenesis, including Tbx2, Tbx3, Wnt11, Shh, and Pitx2. Our findings demonstrate that β-catenin signaling regulates proliferation and survival of cardiac progenitors.

Original language	English
Pages (from-to)	9313-9318
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	104
Issue number	22
DOIs	https://doi.org/10.1073/pnas.0700923104
State	Published - 29 May 2007
Externally published	Yes

Keywords

Cardiac morphogenesis
Cardiac progenitors
Direct target
Isl1

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10.1073/pnas.0700923104

Cite this

Lin, L., Cui, L., Zhou, W., Dufort, D., Zhang, X., Cai, C. L., Bu, L., Yang, L., Martin, J., Kemler, R., Rosenfeld, M. G., Chen, J., & Evans, S. M. (2007). β-Catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis. Proceedings of the National Academy of Sciences of the United States of America, 104(22), 9313-9318. https://doi.org/10.1073/pnas.0700923104

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title = "β-Catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis",

abstract = "Recent studies have demonstrated that the LIM homeodomain transcription factor Islet1 (Isl1) marks pluripotent cardiovascular progenitor cells and is required for proliferation, survival, and migration of recently defined second heart field progenitors. Factors that are upstream of Isl1 in cardiovascular progenitors have not yet been defined. Here we demonstrate that β-catenin is required for Isl1 expression in cardiac progenitors, directly regulating the Isl1 promoter. Ablation of β-catenin in Isl1-expressing progenitors disrupts multiple aspects of cardiogenesis, resulting in embryonic lethality at E13. β-Catenin is also required upstream of a number of genes required for pharyngeal arch, outflow tract, and/or atrial septal morphogenesis, including Tbx2, Tbx3, Wnt11, Shh, and Pitx2. Our findings demonstrate that β-catenin signaling regulates proliferation and survival of cardiac progenitors.",

keywords = "Cardiac morphogenesis, Cardiac progenitors, Direct target, Isl1",

author = "Lizhu Lin and Li Cui and Wenlai Zhou and Daniel Dufort and Xiaoxue Zhang and Cai, \{Chen Leng\} and Lei Bu and Lei Yang and Jody Martin and Rolf Kemler and Rosenfeld, \{Michael G.\} and Ju Chen and Evans, \{Sylvia M.\}",

year = "2007",

month = may,

day = "29",

doi = "10.1073/pnas.0700923104",

language = "English",

volume = "104",

pages = "9313--9318",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

publisher = "National Academy of Sciences",

number = "22",

}

Lin, L, Cui, L, Zhou, W, Dufort, D, Zhang, X, Cai, CL, Bu, L, Yang, L, Martin, J, Kemler, R, Rosenfeld, MG, Chen, J & Evans, SM 2007, 'β-Catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis', Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 22, pp. 9313-9318. https://doi.org/10.1073/pnas.0700923104

β-Catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis. / Lin, Lizhu; Cui, Li; Zhou, Wenlai et al.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, No. 22, 29.05.2007, p. 9313-9318.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - β-Catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis

AU - Lin, Lizhu

AU - Cui, Li

AU - Zhou, Wenlai

AU - Dufort, Daniel

AU - Zhang, Xiaoxue

AU - Cai, Chen Leng

AU - Bu, Lei

AU - Yang, Lei

AU - Martin, Jody

AU - Kemler, Rolf

AU - Rosenfeld, Michael G.

AU - Chen, Ju

AU - Evans, Sylvia M.

PY - 2007/5/29

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AB - Recent studies have demonstrated that the LIM homeodomain transcription factor Islet1 (Isl1) marks pluripotent cardiovascular progenitor cells and is required for proliferation, survival, and migration of recently defined second heart field progenitors. Factors that are upstream of Isl1 in cardiovascular progenitors have not yet been defined. Here we demonstrate that β-catenin is required for Isl1 expression in cardiac progenitors, directly regulating the Isl1 promoter. Ablation of β-catenin in Isl1-expressing progenitors disrupts multiple aspects of cardiogenesis, resulting in embryonic lethality at E13. β-Catenin is also required upstream of a number of genes required for pharyngeal arch, outflow tract, and/or atrial septal morphogenesis, including Tbx2, Tbx3, Wnt11, Shh, and Pitx2. Our findings demonstrate that β-catenin signaling regulates proliferation and survival of cardiac progenitors.

KW - Cardiac morphogenesis

KW - Cardiac progenitors

KW - Direct target

KW - Isl1

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AN - SCOPUS:34250888462

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JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 22

ER -

β-Catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis

Abstract

Keywords

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