α-synuclein in the inner retina in parkinson disease

Ivan Bodis-Wollner; Piotr B. Kozlowski; Sofya Glazman; Shahnaz Miri

doi:10.1002/ana.24182

α-synuclein in the inner retina in parkinson disease

Ivan Bodis-Wollner, Piotr B. Kozlowski, Sofya Glazman, Shahnaz Miri

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178 Scopus citations

Abstract

Behavioral, electrophysiological, and imaging data reveal impaired visual processing and altered retinal morphology in Parkinson disease. Are visual changes epiphenomena? We report the presence of misfolded α-synuclein in the retina, not hitherto shown, in discrete retinal neurons within the inner retina. They demonstrate the histopathology that may underlie impaired vision and retinal remodeling in Parkinson disease. Furthermore, the histological localization of α-synuclein gives clues to the nonsynaptic mode of α-synuclein propagation. ANN NEUROL 2014;75:964-966

Original language	English
Pages (from-to)	964-966
Number of pages	3
Journal	Annals of Neurology
Volume	75
Issue number	6
DOIs	https://doi.org/10.1002/ana.24182
State	Published - Jun 2014
Externally published	Yes

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title = "α-synuclein in the inner retina in parkinson disease",

abstract = "Behavioral, electrophysiological, and imaging data reveal impaired visual processing and altered retinal morphology in Parkinson disease. Are visual changes epiphenomena? We report the presence of misfolded α-synuclein in the retina, not hitherto shown, in discrete retinal neurons within the inner retina. They demonstrate the histopathology that may underlie impaired vision and retinal remodeling in Parkinson disease. Furthermore, the histological localization of α-synuclein gives clues to the nonsynaptic mode of α-synuclein propagation. ANN NEUROL 2014;75:964-966",

author = "Ivan Bodis-Wollner and Kozlowski, \{Piotr B.\} and Sofya Glazman and Shahnaz Miri",

year = "2014",

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AU - Kozlowski, Piotr B.

AU - Glazman, Sofya

AU - Miri, Shahnaz

PY - 2014/6

Y1 - 2014/6

N2 - Behavioral, electrophysiological, and imaging data reveal impaired visual processing and altered retinal morphology in Parkinson disease. Are visual changes epiphenomena? We report the presence of misfolded α-synuclein in the retina, not hitherto shown, in discrete retinal neurons within the inner retina. They demonstrate the histopathology that may underlie impaired vision and retinal remodeling in Parkinson disease. Furthermore, the histological localization of α-synuclein gives clues to the nonsynaptic mode of α-synuclein propagation. ANN NEUROL 2014;75:964-966

AB - Behavioral, electrophysiological, and imaging data reveal impaired visual processing and altered retinal morphology in Parkinson disease. Are visual changes epiphenomena? We report the presence of misfolded α-synuclein in the retina, not hitherto shown, in discrete retinal neurons within the inner retina. They demonstrate the histopathology that may underlie impaired vision and retinal remodeling in Parkinson disease. Furthermore, the histological localization of α-synuclein gives clues to the nonsynaptic mode of α-synuclein propagation. ANN NEUROL 2014;75:964-966

UR - https://www.scopus.com/pages/publications/84903711793

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JO - Annals of Neurology

JF - Annals of Neurology

IS - 6

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α-synuclein in the inner retina in parkinson disease

Abstract

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