Épidémiologie et facteurs de risque des maladies inflammatoires chroniques de l'intestin

Translated title of the contribution: Epidemiology and risk factors of inflammatory bowel diseases

Jean Frédéric Colombel, Gwenola Vernier-Massouille, Antoine Cortot, Corinne Gower-Rousseau, Jean Louis Salomez

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Inflammatory bowel diseases (IBD) are apublic health problem in industrialized countries, where 1 in 1000 people are affected. Most patients are young adults. The incidence of IBD has increased considerably in western countries since the second world war but is beginning to level off. On the other hand, the incidence is still rising in low-incidence areas such as Eastern Europe, Asia and developing countries. Differences in incidence rates across age, time, and geographic areas suggest that environmental factors are involved in IBD, but only cigarette smoking and appendectomy have consistently been identified as risk factors. An important role of genetic factors in IBD was first suggested by epidemiological studies showing familial aggregation of IBD and by twin studies. In 2001, the first CD susceptibility gene, NOD2ICARD15 on chromosome 16, was characterized. Other susceptibility genes have since been located. Their identification should help to understand the complex interaction between the environment and the intestinal immune system.

Translated title of the contributionEpidemiology and risk factors of inflammatory bowel diseases
Original languageFrench
Pages (from-to)1105-1123
Number of pages19
JournalBulletin de l'Academie Nationale de Medecine
Issue number6
StatePublished - Jun 2007
Externally publishedYes


  • Colitis, ulcerative
  • Crohn disease
  • Inflammatory bowel diseases


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