Toll-like Receptor Control of MHC Class I Endocytosis

PROJECT NARRATIVE MHC class I molecules present peptides at the cell surface to CD8 T cells. MHC-I endocytosis is important for its loading with peptides from internalized antigens, but how this process is regulated is unknown. The work we propose here to understand this biology will inform the design of urgently needed vaccines against clinically important viruses such as HIV, Ebola, and Dengue as well as novel pandemic strains of viruses.