Targeting monocyte recruitment and macrophage function for perineural invasion

Project Details


Dr. Bakst and his research group previously demonstrated that the immune system plays a significant role in promoting nerve invasion by cancer. In response to cancer, the nerve secretes a molecule that recruits circulating monocytes, which arrive at the nerve and promote nerve invasion through the production of a specific enzyme that disrupts protective layers surrounding nerves. Dr. Bakst and his research group aim to target this conserved innate immune response to impair nerve invasion.
Effective start/end date1/01/18 → …


  • American Association for Cancer Research


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