Relationships between dentate gyrus synaptic subtypes and age-related memory impairment in rhesus monkesy

Project Details


Age-related memory impairment occurs in many mammalian species, including humans. Many women undergoing the menopausal transition also report problems with memory. Dr. Hara will examine the dentate gyrus (DG), a brain area particularly vulnerable to the effects of aging, and its synapses (junctions between nerve cells that transmit and receive nerve impulses,). She will study rhesus monkeys because they develop age-related deficits in DG-dependent memory and undergo menopause similar to humans. The overall goal of her project is to determine the subtypes of DG synapses that are selectively vulnerable to aging. Findings will have major implications for normal age-related memory impairment as well as for menopause-associated cognitive symptoms in humans. In addition, the results may further lead to potential behavioral therapies and/or pharmacological agents that help protect the subtypes of DG synapses that are vulnerable to aging.
Effective start/end date1/01/10 → …


  • American Federation for Aging Research


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