Preconceptual Bisphenol and Phthalate Effects on Early Embryonic Development

Project Narrative Studies of phthalate and bisphenol exposure in pregnancy and their impact on growth have been limited by lack of data regarding exposures before conception and in early embryonic development. The proposed work leverages a large Dutch cohort begun before conception to examine exposures to these chemicals, especially those emerging as replacements for bisphenol A and di-2-ethyl-hexylphthalate. If preconceptional exposures are found to be important in shaping fetal growth and influencing birth outcomes, then guidance in anticipation of conception to limit environmental exposures before pregnancy may be indicated.