Novel Cellular Factors Required for HCMV Entry and Infection

  • Gardner, Thomas (PI)

Project Details

Description

The co-opting of cellular proteins to allow virus entry and propagation is a well-established requirement of Human Cytomegalovirus (HCMV) infection. HCMV encodes a large number of glycoproteins and is known to have complex interactions with cellular factors, yet very little is known about cell-surface requirements and bona fide cellular receptors involved in HCMV fusion. This study will identify novel cellular factors required for HCMV entry and infection and will provide the foundation for future studies that decipher the molecular details of how HCMV utilizes cellular components to bind and infect cells. The identification of host factors required for HCMV entry and proliferation will lead to a better understanding of viral lifecycle and the development of therapeutics to target multiple phases of CMV proliferation. Our method of identifying novel host factors will allow simultaneous development of anti-HCMV therapeutics that can be used to alleviate and prevent HCMV disease in the immuno-compromised, including vascular disease patients and transplant recipients. (AHA Program: Predoctoral Fellowship)

StatusFinished
Effective start/end date1/07/1330/06/15

Funding

  • American Heart Association: $44,000.00

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