Mechanism of BET Proteins in Th17 Cell Differentiation

PROJECT SUMMARY This administrative supplement application is submitted for the parent award (5R01AI124465) in response to NIAID?s Notice of Special Interest (NOT-AI-20-031) ?Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) and Coronavirus Disease 2019 (COVID-19)?, as well as ?Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp - Clinical Trial Optional)? (PA-18-591). The outbreak of the new coronavirus (SARS-CoV-2) infection is spreading to every continent around the world at an astonishing speed. As of April 15, 2020, coronavirus disease 2019 (COVID-19) has been confirmed in 2,035,764 people worldwide, causing a mortality of 6.42%, exceeding far beyond a mortality rate of