Investigating the Tissue and Isoform Specific Roles of Glycogen Synthase Kinase 3 in Atherogenesis

    Project Details

    Description

    Cardiovascular disease is the leading cause of death in Western societies. Cardiovascular risk factors include diabetes, smoking, obesity and lack of exercise. It is not known exactly how these risk factors promote the development of cardiovascular disease. We have recently found a role for the protein Glycogen Synthase Kinase (GSK)-3 during the development of cardiovascular disease. I will expand this research by investigating the role of GSK3 in specific tissues. Further, I will analyze the role of different forms of the GSK3 protein, specifically the alpha form and the beta form. This research may identify novel therapeutic targets to halt or reverse the progression of cardiovascular disease.

    StatusFinished
    Effective start/end date1/09/1231/08/15

    Funding

    • Institute of Nutrition, Metabolism and Diabetes: $105,053.00

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