Increasing cognitive performance, neuronal plasticity and survival using non-invasive delivery of neurotrophic genes

  • Weber-Adrian, Danielle (PI)
  • Aubert, Isabelle I. (CoI)
  • Hynynen, Kullervo H K.H. (CoI)

Project Details

Description

This experiment will investigate the therapeutic potential of non-invasive gene delivery for the treatment of Alzheimer's disease (AD). We propose delivering brain derived neurotrophic factor (BDNF) or a BDNF receptor-specific agonist to the brain using MRI-guided focused ultrasound. The results of these experiments could demonstrate a novel AD treatment strategy using targeted gene delivery to restore memory.

StatusFinished
Effective start/end date1/09/1631/08/17

Funding

  • Institute of Neurosciences, Mental Health and Addiction: $79,287.00

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