Immunometabolism of IgA-Microbiota Interaction in Gut Homeostasis and Inflammation

Primary immunodeficiencies (PIDs) can be regarded as experiments of nature that can help us to better understand the regulation and function of human immune responses. In this proposal, we will combine the study of blood, tissue and stool specimens from PID patients with the analysis of genetically engineered, gnotobiotic and humanized microbiota mouse models to better understand the genesis and function of intestinal IgA antibodies. The proposed studies will provide unprecedented insights into host-microbiota interaction in humans and offer new clues as to the pathogenesis and treatment of inflammatory, autoimmune and metabolic disorders that often arise in patients with PIDs.