Genomics of prostate cancer: From gene identification to clinical applications

  • Grönberg, Henrik H. (PI)
  • Wiklund, Peter (CoPI)
  • Wiklund, Fredrik F. (CoPI)
  • Lindberg, Johan J. (CoPI)
  • Egevad, Lars L. (CoPI)

Project Details

Description

AIM: The overarching aim of the proposed studies is to identify genes and genetic variation of importance for prostate cancer risk and eventually progression of prostate cancer and to translate these findings into clinical management of prostate cancer.BACKGROUND: Prostate cancer is the most common cancer and the leading cause of cancer death among men in Sweden. In year 2011 over 10.000 men were diagnosed with prostate cancer and over 2500 would die of the disease. At least 70 genetic variants have been identified to associate with prostate cancer.WORK PLAN: We have access to several large population-based populations and tumour studies with prostate cancer. We are planning several clinical trials were the clinical utility of new biomarkers including genetic markers are evaluated.SIGNIFICANCE: This study proposal addresses a disease with a significant public health impact as prostate cancer kills over 2500 men each year in Sweden. In this research program there is a wide range of studies from identification of genetic variants associated with prostate cancer, identification of tumor biomarkers for progression to clinical translation of these findings. The main key areas are: - Develop genetic test for prostate cancer diagnostics - Identify tumor molecular markers for progression of localized prostate cancer - To initiate randomized clinical trials in prostate cancer using genomic markers

StatusFinished
Effective start/end date1/01/1331/12/16

Funding

  • Vetenskapsrådet: $798,477.00

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