Finding Novel Splicing Factors and RNA-binding Proteins that Alter Tau

  • BOWLES , KATHRYN (PI)

Project Details

Description

Alzheimer's disease (AD) is part of a larger group of diseases that cause a protein known as 'tau' to accumulate abnormally in the brain. Normally, in the healthy brain, tau fulfills several functions critical for neuron health, and to carry out those assignments, it has the ability to change its length and features through a process known as splicing. However, tau can also undergo detrimental changes that cause it to mistakenly include the wrong features, including to become misshapen and devolve into neurofibrillary tangles that destabilize neurons. This transformation leads to a class of neurodegenerative diseases known as 'tauopathies.' There are six different versions of tau protein in the human brain, and it is thought that an imbalance of the different versions result in their abnormal accumulation and subsequent development of a tauopathy. This project aims to discover what genes are responsible for regulating the different versions of tau so that we may better understand how and why an imbalance occurs, and what we could do to fix it.
StatusFinished
Effective start/end date1/07/1730/06/19

Funding

  • BrightFocus Foundation: $100,000.00

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