Project Details

Description

In exfoliation syndrome (XFS), the eye starts accumulating protein aggregates that resemble fluffy white deposits. Eventually this debris may block the exit of fluid from the eye, causing a buildup of pressure that is believed to contribute to glaucoma and optic nerve damage. If unchecked, these changes can lead to blindness. We have discovered that cells obtained from XFS eyes may have a problem degrading these protein aggregates, leading to the toxic accumulation of this form of 'cellular trash.' Our project will test methods to accelerate degradation of this cellular waste in order to improve the health of XFS-affected eyes.
StatusFinished
Effective start/end date1/07/1530/06/16

Funding

  • BrightFocus Foundation: $50,000.00

Fingerprint

Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.