ENVIRONMENTAL TRIGGERS OF TYPE 1 DIABETES MELLITUS

  • Palacios, Gustavo (PI)

Project Details

Description

My hypothesis is that type I diabetes mellitus (T1DM) is initiated in high risk children by a microbial infection. This is not a new concept; nonetheless, the diagnostic tools and clinical samples required to rigorously explore this concept have only recently been established. My project will exploit sensitive comprehensive molecular diagnostic technologies and biological samples obtained regularly from a large group of individuals before the beginning of the disease. Samples will be drawn from two large groups of children at increased risk of T1DM (Diabetes Autoimmunity Study in the Young; DAISY): 1) a cohort of 849 siblings and offspring of persons with T1DM and 2) a cohort of 1,184 newborns with T1DM-associated genetic background, identified through a screening at birth of over 31,000 children from the general population. Additional samples from the TEDDY study will be also studied as soon as they become available. Two new diagnostic platforms invented in the Greene Laboratory will be used: Mass Tag PCR and GreeneChip microarrays. The clinical implications of discovering an infectious trigger for T1DM would be profound. Recent examples that underscore this point include the association of Helicobacter pylori and ulcer disease which culminated in the 2005 Nobel Prize for Marshall and Warren, and the association of papilloma virus and cervical cancer that resulted in the development of the first anti-cancer vaccine.

StatusFinished
Effective start/end date1/09/0731/08/10

Funding

  • Juvenile Diabetes Research Foundation United States of America: $480,196.00

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