Project Details


Blast-related mild traumatic brain injury (mTBI) is common among Service members and Veterans who served in Iraq and Afghanistan. TBI has many long-term adverse health consequences as summarized in a recent report by the Institute of Medicine. However, it remains unclear if TBI increases the susceptibility to diabetes and other metabolic diseases. Given the tremendous impact that diabetes and metabolic diseases have on the quality of life and morbidity by fueling cardiovascular disease, cancer, impaired cognition, and reducing life expectancy, it is important to establish if mTBI can indeed cause metabolic disease and if so, through which mechanisms. Here we will examine if mTBI increases susceptibility to diabetes as suggested by our preliminary data. In these studies, we aim to identify the mechanisms by which mTBI causes prediabetes and will test strategies to prevent or reduce the susceptibility of diabetes after mTBI.

Effective start/end date1/01/17 → …


  • Congressionally Directed Medical Research Programs: $279,129.00


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