Project Details


Project SummaryWorld Trade Center (WTC) first responders have suffered numerous diseases and conditions as a result oftheir efforts on 9/11 and afterwards. For example, it has been noted that there are numerous cases ofaerodigestive disorders amongst the responders, including sinusitis, asthma, interstitial lung disease, andgastroesophageal reflux. Similarly, there are reports of higher than expected rates of certain cancers, such asmultiple myeloma, prostate, and thyroid. Also reported are relatively high rates of post-traumatic stressdisorder, anxiety, depression, and sleep apnea. The commonality in these reports is the comparator groupsagainst which the data from the WTC General Responders Cohort (WTC-GRC) were measured. Thecomparator groups were either national or local (e.g., the NY State Cancer Registry) and were composed ofmembers of the general population, not occupational groups. The purpose of this proposal is the developmentof a unique occupational cohort, based in part on patients attending the Mount Sinai Selikoff Centers forOccupational Health (SCOH), as well as workers presenting to other departments within Mount Sinai, andworkers recruited through outreach efforts. The reasoning is that for valid estimates of the health of the firstresponders, comparisons must be against a working population and not the general population, which can leadto intractable bias and faulty assessments.The specific aims of the proposed project include: 1) converting existing SCOH data into a usable database forcomparative analyses of WTC-related health conditions; 2) building a new occupational cohort to serve as acomparison in the longitudinal assessment of health in the WTC-GRC; and 3) utilizing the newly createdcomparison cohort to determine if gastroesophageal reflux disease (GERD) incidence in the WTC-GRC differsfrom an unexposed worker population.The results of the proposed project will improve the quality of the health related studies being done byproviding a more appropriate comparison group that can be matched to responders on several importantcharacteristics, including occupation, age, sex and race/ethnicity. Such studies will result in improvedestimates of disease risk and add important knowledge to what we currently understand about exposure to9/11 toxins and stressors.

Effective start/end date1/07/1830/06/21


  • National Institute for Occupational Safety and Health: $499,991.00


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