Characterizing the Biologic Evolution of Crohn's Disease Like Pouch Inflammation in Ulcerative Colitis Patients After Restorative Proctocolectomy with Ileal Pouch Anal Anastomosis

Project Details

Description

Up to 30% of patients with treatment refractory ulcerative colitis (UC) require colon removal and the creation of an ileal pouch anal anastomosis (IPAA) to serve as an internal pelvic stool reservoir and allow for defecation per anus. Approximately 20% of patients with an IPAA develop Crohn’s disease-like pouch inflammation (CDLPI) which causes symptoms similar to their original UC, and up to 50% of these patients do not respond to therapy and require surgical pouch removal and the creation of a permanent ostomy. We aim to characterize the genetic variants, ileal transcriptome, microbial and metabolomic profiles associated with CDLPI in patients with UC after IPAA in order to identify predictive disease markers and potential therapeutic strategies.
StatusFinished
Effective start/end date1/02/2231/01/23

Funding

  • National Institute of Diabetes and Digestive and Kidney Diseases: $190,904.00

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