Project Details


ABSTRACT Acute kidney injury (AKI) affects up to half of critically ill patients admitted to intensive care units (ICU). In patients with AKI and hemodynamic instability, continuous renal replacement therapy (CRRT) is the preferred dialysis modality for solute and volume control. ICU mortality in this vulnerable population is high (~75%) but kidney recovery occurs in up to two-thirds of survivors. Fluid overload is a potentially modifiable risk factor associated with these outcomes. However, there are currently no universally accepted approaches for predicting kidney recovery, survival or individual response to fluid removal during CRRT. Due to recent advances in computer science and widespread big data usage, deep learning (DL) has emerged as a valuable approach. DL allows construction of risk prediction models using time-series data that incorporate thousands of variables and dynamic changes in these variables derived from multi-dimensional sources and not only static values of these variables. We propose to develop and validate innovative DL approaches to dynamically predict these outcomes using multi-modal data from electronic health records and CRRT machines. We demonstrated superiority of DL models without a-priori variable selection compared to optimized logistic regression (C-Statistic of 0.72 vs. 0.62) for prediction of RRT liberation. We also showed that mortality prediction improved by incorporating changes in clinical data within 6-hour intervals after CRRT initiation. In addition, we identified distinctive mortality risk according to quintiles of achieved net ultrafiltration rates, after adjustment by patient?s weight, duration of CRRT, and other clinical parameters: OR 8.0 (95% CI: 2.7-25.1) when the highest quintile (>36 ml/kg/day) was compared to the lowest quintile (
Effective start/end date19/09/2031/08/21


  • National Institute of Diabetes and Digestive and Kidney Diseases: $100,000.00


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