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PROFESSOR | Neurology, Neuroscience
Biography
Molecular, Cellular, Behavioral Biology and Translational Research in Neurodegeneration Our long-term goal is to understand the molecular and cellular mechanisms of neurodegeneration that causes human neurological disorders such as Parkinson’s, Huntington’s and Alzheimer’s diseases. Our mission is to translate our knowledge from basic research to the development of molecular diagnostics and therapeutics for neurological disorders. Our primary research interests encompass molecular and cellular pathways for autophagy-lysosome degradation, protein quality control (aggregate clearance), synaptic vesicle trafficking, neuroinflammation, and protein/lipid kinase signaling in neuropathogenesis. Other Web Sites http://www.mountsinai.org/Research/Centers%20Laboratories%20and%20Programs/Yue%20Laboratory Yue Laboratory Multi-Disciplinary Training Areas Biophysics and Systems Pharmacology [BSP], Neuroscience [NEU]
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Collaborations and top research areas from the last five years
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New Multiomic Studies Shed Light on Cellular Diversity and Neuronal Susceptibility in Parkinson's Disease
Liang, M., Chu, L. & Yue, Z., Mar 2025, In: Movement Disorders. 40, 3, p. 431-437 7 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Integrated proteomics reveals autophagy landscape and an autophagy receptor controlling PKA-RI complex homeostasis in neurons
Zhou, X., Lee, Y. K., Li, X., Kim, H., Sanchez-Priego, C., Han, X., Tan, H., Zhou, S., Fu, Y., Purtell, K., Wang, Q., Holstein, G. R., Tang, B., Peng, J., Yang, N. & Yue, Z., Dec 2024, In: Nature Communications. 15, 1, 3113.Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations -
International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis
Chen, X., Tsvetkov, A. S., Shen, H. M., Isidoro, C., Ktistakis, N. T., Linkermann, A., Koopman, W. J. H., Simon, H. U., Galluzzi, L., Luo, S., Xu, D., Gu, W., Peulen, O., Cai, Q., Rubinsztein, D. C., Chi, J. T., Zhang, D. D., Li, C., Toyokuni, S. & Liu, J. & 49 others, , 2024, In: Autophagy. 20, 6, p. 1213-1246 34 p.Research output: Contribution to journal › Review article › peer-review
Open Access150 Scopus citations -
Molecular profiling of human substantia nigra identifies diverse neuron types associated with vulnerability in Parkinson’s disease
Wang, Q., Wang, M., Choi, I., Sarrafha, L., Liang, M., Ho, L., Farrell, K., Beaumont, K. G., Sebra, R., De Sanctis, C., Crary, J. F., Ahfeldt, T., Blanchard, J., Neavin, D., Powell, J., Davis, D. A., Sun, X., Zhang, B. & Yue, Z., Jan 2024, In: Science advances. 10, 2, eadi8287.Research output: Contribution to journal › Article › peer-review
Open Access48 Scopus citations -
RAB12-LRRK2 complex suppresses primary ciliogenesis and regulates centrosome homeostasis in astrocytes
Li, X., Zhu, H., Huang, B. T., Li, X., Kim, H., Tan, H., Zhang, Y., Choi, I., Peng, J., Xu, P., Sun, J. & Yue, Z., Dec 2024, In: Nature Communications. 15, 1, 8434.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations
Press/Media
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Research Results from Icahn School of Medicine at Mount Sinai Update Understanding of Bipolar Disorders (Bipolar and schizophrenia risk gene AKAP11 encodes an autophagy receptor coupling the regulation of PKA kinase network homeostasis to ...)
Yang, N., Yue, Z., Lee, K. & Dai, J.
11/12/25
1 item of Media coverage
Press/Media
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Data on Life Science Discussed by Researchers at Icahn School of Medicine at Mount Sinai (Cortical tension as a mechanical barrier to safeguard against premature differentiation during neurogenesis)
Kang, S. & Yue, Z.
13/10/25
1 item of Media coverage
Press/Media