Research output per year
Research output per year
Personal profile
Headline
PROFESSOR | Neurology, Neuroscience
Biography
Molecular, Cellular, Behavioral Biology and Translational Research in Neurodegeneration Our long-term goal is to understand the molecular and cellular mechanisms of neurodegeneration that causes human neurological disorders such as Parkinson’s, Huntington’s and Alzheimer’s diseases. Our mission is to translate our knowledge from basic research to the development of molecular diagnostics and therapeutics for neurological disorders. Our primary research interests encompass molecular and cellular pathways for autophagy-lysosome degradation, protein quality control (aggregate clearance), synaptic vesicle trafficking, neuroinflammation, and protein/lipid kinase signaling in neuropathogenesis. Other Web Sites http://www.mountsinai.org/Research/Centers%20Laboratories%20and%20Programs/Yue%20Laboratory Yue Laboratory Multi-Disciplinary Training Areas Biophysics and Systems Pharmacology [BSP], Neuroscience [NEU]
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Collaborations and top research areas from the last five years
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Integrated proteomics reveals autophagy landscape and an autophagy receptor controlling PKA-RI complex homeostasis in neurons
Zhou, X., Lee, Y. K., Li, X., Kim, H., Sanchez-Priego, C., Han, X., Tan, H., Zhou, S., Fu, Y., Purtell, K., Wang, Q., Holstein, G. R., Tang, B., Peng, J., Yang, N. & Yue, Z., Dec 2024, In: Nature Communications. 15, 1, 3113.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis
Chen, X., Tsvetkov, A. S., Shen, H. M., Isidoro, C., Ktistakis, N. T., Linkermann, A., Koopman, W. J. H., Simon, H. U., Galluzzi, L., Luo, S., Xu, D., Gu, W., Peulen, O., Cai, Q., Rubinsztein, D. C., Chi, J. T., Zhang, D. D., Li, C., Toyokuni, S. & Liu, J. & 49 others, , 2024, In: Autophagy. 20, 6, p. 1213-1246 34 p.Research output: Contribution to journal › Review article › peer-review
Open Access18 Scopus citations -
Molecular profiling of human substantia nigra identifies diverse neuron types associated with vulnerability in Parkinson’s disease
Wang, Q., Wang, M., Choi, I., Sarrafha, L., Liang, M., Ho, L., Farrell, K., Beaumont, K. G., Sebra, R., De Sanctis, C., Crary, J. F., Ahfeldt, T., Blanchard, J., Neavin, D., Powell, J., Davis, D. A., Sun, X., Zhang, B. & Yue, Z., Jan 2024, In: Science advances. 10, 2, eadi8287.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Silencing Parkinson’s risk allele Rit2 sex-specifically compromises motor function and dopamine neuron viability
Kearney, P. J., Zhang, Y., Liang, M., Tan, Y., Kahuno, E., Conklin, T. L., Fagan, R. R., Pavchinskiy, R. G., Shaffer, S. A., Yue, Z. & Melikian, H. E., Dec 2024, In: npj Parkinson's Disease. 10, 1, 41.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Autophagy enables microglia to engage amyloid plaques and prevents microglial senescence
Choi, I., Wang, M., Yoo, S., Xu, P., Seegobin, S. P., Li, X., Han, X., Wang, Q., Peng, J., Zhang, B. & Yue, Z., Jul 2023, In: Nature Cell Biology. 25, 7, p. 963-974 12 p.Research output: Contribution to journal › Article › peer-review
Open Access38 Scopus citations
Press/Media
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EPISODE 21: THE AUTOPHAGY-LYSOSOMAL PATHWAY AND DEVELOPMENT OF RELEVANT PD BIOMARKERS WITH ZHENYU YUE
20/08/24
1 item of Media coverage
Press/Media
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Icahn School of Medicine at Mount Sinai Researchers Update Knowledge of Protein Kinase A (Integrated proteomics reveals autophagy landscape and an autophagy receptor controlling PKA-RI complex homeostasis in neurons)
Yang, N., Wang, Q., Purtell, K., Holstein, G., Lee, K. & Yue, Z.
30/04/24
1 item of Media coverage
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Icahn School of Medicine at Mount Sinai Details Findings in Parkinson's Disease (Molecular Profiling of Human Substantia Nigra Identifies Diverse Neuron Types Associated With Vulnerability In Parkinson's Disease)
Farrell, K., Blanchard, J., Wang, Q., Sebra, R., Wang, M., Ho, L. & Yue, Z.
21/03/24
1 item of Media coverage
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Lower RIT2 gene activity implicated in Parkinson’s development
19/01/24
1 item of Media coverage
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WHAT WE FUND: $17.8M TOWARD RESEARCH INTO BIOMARKERS, GENE THERAPY, GENETICS AND THE ROLE OF THE BLOOD-BRAIN BARRIER IN PD
Saunders-Pullman, R. & Yue, Z.
18/12/23
1 item of Media coverage
Press/Media