Research output per year
Research output per year
Personal profile
Headline
PROFESSOR | Neurology, Neuroscience
Biography
Molecular, Cellular, Behavioral Biology and Translational Research in Neurodegeneration Our long-term goal is to understand the molecular and cellular mechanisms of neurodegeneration that causes human neurological disorders such as Parkinson’s, Huntington’s and Alzheimer’s diseases. Our mission is to translate our knowledge from basic research to the development of molecular diagnostics and therapeutics for neurological disorders. Our primary research interests encompass molecular and cellular pathways for autophagy-lysosome degradation, protein quality control (aggregate clearance), synaptic vesicle trafficking, neuroinflammation, and protein/lipid kinase signaling in neuropathogenesis. Other Web Sites http://www.mountsinai.org/Research/Centers%20Laboratories%20and%20Programs/Yue%20Laboratory Yue Laboratory Multi-Disciplinary Training Areas Biophysics and Systems Pharmacology [BSP], Neuroscience [NEU]
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Collaborations and top research areas from the last five years
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New Multiomic Studies Shed Light on Cellular Diversity and Neuronal Susceptibility in Parkinson's Disease
Liang, M., Chu, L. & Yue, Z., Mar 2025, In: Movement Disorders. 40, 3, p. 431-437 7 p.Research output: Contribution to journal › Article › peer-review
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Integrated proteomics reveals autophagy landscape and an autophagy receptor controlling PKA-RI complex homeostasis in neurons
Zhou, X., Lee, Y. K., Li, X., Kim, H., Sanchez-Priego, C., Han, X., Tan, H., Zhou, S., Fu, Y., Purtell, K., Wang, Q., Holstein, G. R., Tang, B., Peng, J., Yang, N. & Yue, Z., Dec 2024, In: Nature Communications. 15, 1, 3113.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis
Chen, X., Tsvetkov, A. S., Shen, H. M., Isidoro, C., Ktistakis, N. T., Linkermann, A., Koopman, W. J. H., Simon, H. U., Galluzzi, L., Luo, S., Xu, D., Gu, W., Peulen, O., Cai, Q., Rubinsztein, D. C., Chi, J. T., Zhang, D. D., Li, C., Toyokuni, S. & Liu, J. & 49 others, , 2024, In: Autophagy. 20, 6, p. 1213-1246 34 p.Research output: Contribution to journal › Review article › peer-review
57 Scopus citations -
Molecular profiling of human substantia nigra identifies diverse neuron types associated with vulnerability in Parkinson’s disease
Wang, Q., Wang, M., Choi, I., Sarrafha, L., Liang, M., Ho, L., Farrell, K., Beaumont, K. G., Sebra, R., De Sanctis, C., Crary, J. F., Ahfeldt, T., Blanchard, J., Neavin, D., Powell, J., Davis, D. A., Sun, X., Zhang, B. & Yue, Z., Jan 2024, In: Science advances. 10, 2, eadi8287.Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations -
RAB12-LRRK2 complex suppresses primary ciliogenesis and regulates centrosome homeostasis in astrocytes
Li, X., Zhu, H., Huang, B. T., Li, X., Kim, H., Tan, H., Zhang, Y., Choi, I., Peng, J., Xu, P., Sun, J. & Yue, Z., Dec 2024, In: Nature Communications. 15, 1, 8434.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations
Press/Media
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RAB12-LRRK2 complex suppresses primary ciliogenesis and regulates centrosome homeostasis in astrocytes.
30/09/24
1 item of Media coverage
Press/Media
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EPISODE 21: THE AUTOPHAGY-LYSOSOMAL PATHWAY AND DEVELOPMENT OF RELEVANT PD BIOMARKERS WITH ZHENYU YUE
20/08/24
1 item of Media coverage
Press/Media
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Icahn School of Medicine at Mount Sinai Researchers Update Knowledge of Protein Kinase A (Integrated proteomics reveals autophagy landscape and an autophagy receptor controlling PKA-RI complex homeostasis in neurons)
Yang, N., Wang, Q., Holstein, G., Lee, K. & Yue, Z.
30/04/24
1 item of Media coverage
Press/Media