Projects per year
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PROFESSOR | Neurology, Neuroscience
Biography
Molecular, Cellular, Behavioral Biology and Translational Research in Neurodegeneration Our long-term goal is to understand the molecular and cellular mechanisms of neurodegeneration that causes human neurological disorders such as Parkinson’s, Huntington’s and Alzheimer’s diseases. Our mission is to translate our knowledge from basic research to the development of molecular diagnostics and therapeutics for neurological disorders. Our primary research interests encompass molecular and cellular pathways for autophagy-lysosome degradation, protein quality control (aggregate clearance), synaptic vesicle trafficking, neuroinflammation, and protein/lipid kinase signaling in neuropathogenesis. Other Web Sites http://www.mountsinai.org/Research/Centers%20Laboratories%20and%20Programs/Yue%20Laboratory Yue Laboratory Multi-Disciplinary Training Areas Biophysics and Systems Pharmacology [BSP], Neuroscience [NEU]
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Molecular and Cellular Basis of the Gut-Brain Axis in Parkinsons Disease
Yue, Z. Z., Han, W., Peter, I., Peter, I., Saunders-pullman, R. R., Saunders-Pullman, R., Han, W. W. & Yue, Z.
National Institute of Neurological Disorders and Stroke
15/09/21 → 31/08/23
Project: Research
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Administrative management of Mount Sinai PD consortium
Yue, Z. & Yue, Z. Z.
National Institute of Neurological Disorders and Stroke
1/07/21 → 31/08/23
Project: Research
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Deciphering LRRK2 pathophysiology in mediating gut-brain axis of PD using novel genetic mouse models
Yue, Z. & Yue, Z. Z.
National Institute of Neurological Disorders and Stroke
1/07/21 → 31/08/23
Project: Research
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Dysfunctional Signaling Mechanism of Neurotransmission in Parkinson's Disease
1/01/15 → …
Project: Research
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Emerging roles of NRBF2/PI3KC3 axis in maintaining homeostasis of brain and guts
Wu, M. Y., Cai, C. Z., Yang, C., Yue, Z., Chen, Y., Bian, Z. X., Li, M. & Lu, J. H., Feb 2022, In: Neural Regeneration Research. 17, 2, p. 323-324 2 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
Enhancing autophagy maturation with CCZ1-MON1A complex alleviates neuropathology and memory defects in Alzheimer disease models
Cai, C. Z., Zhuang, X. X., Zhu, Q., Wu, M. Y., Su, H., Wang, X. J., Iyaswamy, A., Yue, Z., Wang, Q., Zhang, B., Xue, Y., Tan, J., Li, M., He, H. & Lu, J. H., 2022, In: Theranostics. 12, 4, p. 1738-1755 18 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Pharmacological modulation of autophagy for Alzheimer's disease therapy: Opportunities and obstacles
Deng, Z., Dong, Y., Zhou, X., Lu, J. H. & Yue, Z., Apr 2022, In: Acta Pharmaceutica Sinica B. 12, 4, p. 1688-1706 19 p.Research output: Contribution to journal › Review article › peer-review
Open Access3 Scopus citations -
Association of neurogranin gene expression with Alzheimer's disease pathology in the perirhinal cortex
Sun, X., Wang, Q., Blennow, K., Zetterberg, H., McCarthy, M., Loewenstein, D. A., Vontell, R., Yue, Z. & Zhang, B., 2021, In: Alzheimer's and Dementia: Translational Research and Clinical Interventions. 7, 1, e12162.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Autophagy deficiency in neurodevelopmental disorders
Deng, Z., Zhou, X., Lu, J. H. & Yue, Z., Dec 2021, In: Cell and Bioscience. 11, 1, 214.Research output: Contribution to journal › Review article › peer-review
Open Access6 Scopus citations