Projects per year
RESEARCH PROFESSOR Pathology RESEARCH PROFESSOR Medicine, Hematology and Medical Oncology
Dr. Najfeld is an internationally known cancer cytogeneticist who has made major contributions in advancing the concept of multistep clonal evolution in chronic myeloproliferative disorders and hematological malignancies. She established in 1981 an outstanding Tumor Cytogenetics clinical laboratory, which provides service utilizing state-of-the-art technology and methodology. She continues to be at the forefrontin advancing and implementing molecular cytogenetic technology for diagnostic and prognostic purposes of hematological malignancies and solid tumors. Her clinical laboratorycurrently performs over 15,000 cytogenetic and gene alteration clinical tests yearly. Her pioneering research in delineating events involved in the step-wise pathogenesis of chronic myelogenous leukemia served as a ground breaking work for later investigations on the origin and pathogenesis of other hematological malignancies. She has been on editorial board of Leukemia, Blood, and Cancer Genetics and Cytogenetics and organized three scientific symposia at the Mount Sinai Medical Center. She is a scientific reviewer for 15 peer-reviewed journals. She has served in many leadership positions nationally and was the only Ph.D. elected as President of the Society for the Study of Blood, the oldest US hematological society. Dr. Najfeld has given invited lectures throughout the world and is also a respected author of over 100 papers. She has mentored many postdoctoral students and fellows in Hematology/Oncology. Dr. Najfeld received the prestigious Richard E. Rosenfeld Faculty Achievement award from the Department of Medicine, Division of Hematology/Oncology in recognition for excellence in teaching and research in hematological malignancies. Her current research focuses on chromosomal and gene alterations in the process of neoplastic development, specifically multistep pathogenesis and clonal development of Ph negative myeloproliferative neoplasm using FISH for intracellular diagnosis of gene rearrangements in clonally derived CD34+ cells. Her laboratory is the core cytogenetic lab for the NIH funded international program project for Myeloproliferative disease consortium.
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CANCER CENTER SUPPORT GRANT
Holland, J. F., Mendelsohn, J., Najfeld, V. & Suzuki, J.
1/12/84 → 30/11/89
1/10/84 → 30/09/88
Acute myeloid leukemia with an MN1-ETV6 fusion in a young child with Down syndromeRosenzweig, J., Pillai, P. M., Prockop, S., Benayed, R., Brodersen, L. E., Najfeld, V., Loken, M. R., Zhang, Y. & Shukla, N., Apr 2022, In: Cold Spring Harbor molecular case studies. 8, 3, a006167.
Research output: Contribution to journal › Article › peer-review
A randomized phase 3 trial of interferon-α vs hydroxyurea in polycythemia vera and essential thrombocythemiaMascarenhas, J., Kosiorek, H. E., Prchal, J. T., Rambaldi, A., Berenzon, D., Yacoub, A., Harrison, C. N., McMullin, M. F., Vannucchi, A. M., Ewing, J., O'Connell, C. L., Kiladjian, J. J., Mead, A. J., Winton, E. F., Leibowitz, D. S., De Stefano, V., Arcasoy, M. O., Kessler, C. M., Catchatourian, R., Rondelli, D., & 23 others, 12 May 2022, In: Blood. 139, 19, p. 2931-2941 11 p.
Research output: Contribution to journal › Article › peer-reviewOpen Access17 Scopus citations
Characterization of disease-propagating stem cells responsible for myeloproliferative neoplasm–blast phaseWang, X., Rampal, R. K., Hu, C. S., Tripodi, J., Farnoud, N., Petersen, B., Rossi, M. R., Patel, M., McGovern, E., Najfeld, V., Iancu-Rubin, C., Lu, M., Davis, A., Kremyanskaya, M., Weinberg, R. S., Mascarenhas, J. & Hoffman, R., 22 Apr 2022, In: JCI insight. 7, 8, e156534.
Research output: Contribution to journal › Article › peer-reviewOpen Access2 Scopus citations
A library of induced pluripotent stem cells from clinically well-characterized, diverse healthy human individualsSchaniel, C., Dhanan, P., Hu, B., Xiong, Y., Raghunandan, T., Gonzalez, D. M., Dariolli, R., D'Souza, S. L., Yadaw, A. S., Hansen, J., Jayaraman, G., Mathew, B., Machado, M., Berger, S. I., Tripodi, J., Najfeld, V., Garg, J., Miller, M., Surlyn, C. S., Michelis, K. C., & 16 others, 14 Dec 2021, In: Stem Cell Reports. 16, 12, p. 3036-3049 14 p.
Research output: Contribution to journal › Article › peer-reviewOpen Access3 Scopus citations
Clinical Benefit Derived from Decitabine Therapy for Advanced Phases of Myeloproliferative NeoplasmsZhou, S., Tremblay, D., Hoffman, R., Kremyanskaya, M., Najfeld, V., Li, L., Moshier, E. & Mascarenhas, J., Jan 2021, In: Acta Haematologica. 144, 1, p. 48-57 10 p.
Research output: Contribution to journal › Article › peer-review9 Scopus citations