Projects per year
Personal profile
Headline
ASSISTANT PROFESSOR | Developmental and Regenerative Biology, ASSISTANT PROFESSOR | Medicine, Liver Diseases
Biography
Biography For more information, please visit the http://research.mssm.edu/gouonevans/Lab/Welcome.html Gouon-Evans Laboratory website. Research From Liver Development to Cell Therapy for Liver Diseases The Gouon-Evans lab is interested in understanding the liver development and regeneration in mice and human using pluripotent stem cells as a model system and cellular source for liver cell therapy. Projects currently developed in the lab: Understanding early hepatic specification of the endoderm in the mouse: crosstalk between endoderm and endothelial cells Studies in animal models have shown that complex cell-cell interactions are required for hepatic specification and maturation during liver development. Namely, endothelial cells are observed very early around the hepatic endoderm, and in their absence the hepatic endoderm does not expand to form the liver bud. The relevance of the endoderm-endothelial cell interactions is not understood. Using the mouse embryonic stem (ES) cell differentiation system as well as the early mouse embryo, we recently demonstrated that the endothelial cell niche induces hepatic specification through dual repression of Wnt and Notch signaling. Ongoing studies aim at revealing further pathways involved in the endothelial cells – endoderm crosstalk required for hepatic specification. Directed differentiation of pluripotent stem cells toward functional mouse and human hepatocytes for cell Therapy in liver diseases The use of ES or induced pluripotent stem (iPS) cell differentiation cultures to generate functional hepatic cells for cell therapy of liver diseases is still an ongoing challenge. Even though a growing literature has established efficient protocols to generate such cells in vitro, the pluripotent stem cell-derived hepatic cells remain inefficient at repopulating diseased livers. Our research is focused on identifying and modulating the molecular pathways required for successful liver regeneration following hepatic cell transplantation into a liver deficient mouse model. For more information, please visit the http://research.mssm.edu/gouonevans/Lab/Welcome.html Gouon-Evans Laboratory website. The Gouon-Evans Lab is part of http://www.blackfamilystemcell.com/index.html the Black Family Stem Cell Institute, the http://www.mssm.edu/departments-and-institutes/developmental-and-regenerative-biology Departments of Developmental and Regenerative Biology and Medicine, http://www.mssm.edu/departments-and-institutes/medicine/divisions/liver-diseases Division of Liver Diseases. Dr Gouon-Evans is a PF Applicant for http://www.mssm.edu/research/centers/alcoholic-liver-disease-research-center the Mount Sinai Alcoholic Liver Diseases Research Center and for http://research.mssm.edu/eti/gouongrant.htm the Experimental Therapeutics Institute.
Fingerprint
Dive into the research topics where Valerie Gouon-Evans is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
A multi-modular approach for human pluripotent stem cell-based liver regeneration
Gouon-Evans, V. & Gouon-evans, V. B.
National Institute of Diabetes and Digestive and Kidney Diseases
15/09/20 → 31/07/23
Project: Research
-
Endothelial cells in liver development and regeneration
National Institute of Diabetes and Digestive and Kidney Diseases
20/04/10 → 30/09/15
Project: Research
-
Development of hepatocytes from ES cells
National Institute of Diabetes and Digestive and Kidney Diseases
15/09/05 → 30/06/10
Project: Research
-
c-Maf: The magic wand that turns on LSEC fate
Smith, A. R. & Gouon-Evans, V., 7 Apr 2022, In: Cell Stem Cell. 29, 4, p. 491-493 3 p.Research output: Contribution to journal › Comment/debate
-
Fibroblasts to hepatocytes: A nonstop flight into cell therapy for liver diseases?
Gouon-Evans, V. & Fiorotto, R., 2022, (Accepted/In press) In: Hepatology.Research output: Contribution to journal › Editorial
-
Use of Nucleoside Modified mRNA Encoding Regenerative Factors Encapsulated with Lipid Nanoparticles to Alleviate Acute and Chronic Murine Liver Diseases
Gouon-Evans, V., Rizvi, F., Everton, E., Smith, A. R., Ying, T., Pardi, N. & Weissman, D., 1 May 2022, In: FASEB Journal. 36Research output: Contribution to journal › Article › peer-review
Open Access -
Author Correction: Murine liver repair via transient activation of regenerative pathways in hepatocytes using lipid nanoparticle-complexed nucleoside-modified mRNA (Nature Communications, (2021), 12, 1, (613), 10.1038/s41467-021-20903-3)
Rizvi, F., Everton, E., Smith, A. R., Liu, H., Osota, E., Beattie, M., Tam, Y., Pardi, N., Weissman, D. & Gouon-Evans, V., 1 Dec 2021, In: Nature Communications. 12, 1, 2825.Research output: Contribution to journal › Comment/debate
Open Access1 Scopus citations -
Murine liver repair via transient activation of regenerative pathways in hepatocytes using lipid nanoparticle-complexed nucleoside-modified mRNA
Rizvi, F., Everton, E., Smith, A. R., Liu, H., Osota, E., Beattie, M., Tam, Y., Pardi, N., Weissman, D. & Gouon-Evans, V., 1 Dec 2021, In: Nature Communications. 12, 1, 613.Research output: Contribution to journal › Article › peer-review
Open Access26 Scopus citations