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Protection of early embryogenesis and pluripotent stem cells against genetic parasites through a primitive immune system
Zwaka, T. & Zwaka, T. P.
National Institute of Child Health and Human Development
23/03/20 → 28/02/23
Project: Research
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An inquiry into the function of Ronin in embryogenesis and pluripotent stem cells
National Institute of General Medical Sciences
11/07/18 → 31/03/19
Project: Research
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NON-APOPTOTIC ACTION OF CASPASES IN PLURIPOTENT EMBRYONIC STEM CELLS
National Institute of General Medical Sciences
1/08/08 → 31/05/14
Project: Research
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Thanatos-Associated Protein 11 (Thap11) in Human Embryonic Stem Cells
National Institute of General Medical Sciences
1/09/07 → 31/08/10
Project: Research
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Regulatory Networks in Human Embryonic Stem Cells
Goodell, M., Barton, M. A., Behringer, R. R., Cooney, A. J., Goodell, M. M. A., Zwaka, T., Zwaka, T. T. P. & Zwaka, T. P.
1/09/07 → 31/08/14
Project: Research
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Mutations in SARS-CoV-2 variants of concern link to increased spike cleavage and virus transmission
Escalera, A., Gonzalez-Reiche, A. S., Aslam, S., Mena, I., Laporte, M., Pearl, R. L., Fossati, A., Rathnasinghe, R., Alshammary, H., van de Guchte, A., Farrugia, K., Qin, Y., Bouhaddou, M., Kehrer, T., Zuliani-Alvarez, L., Meekins, D. A., Balaraman, V., McDowell, C., Richt, J. A., Bajic, G., & 9 others , 9 Mar 2022, In: Cell Host and Microbe. 30, 3, p. 373-387.e7Research output: Contribution to journal › Article › peer-review
Open Access40 Scopus citations -
Sec61 Inhibitor Apratoxin S4 Potently Inhibits SARS-CoV-2 and Exhibits Broad-Spectrum Antiviral Activity
Pohl, M. O., Martin-Sancho, L., Ratnayake, R., White, K. M., Riva, L., Chen, Q. Y., Lieber, G., Busnadiego, I., Yin, X., Lin, S., Pu, Y., Pache, L., Rosales, R., Déjosez, M., Qin, Y., De Jesus, P. D., Beall, A., Yoh, S., Hale, B. G., Zwaka, T. P., & 5 others , 8 Jul 2022, In: ACS Infectious Diseases. 8, 7, p. 1265-1279 15 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A
White, K. M., Rosales, R., Yildiz, S., Kehrer, T., Miorin, L., Moreno, E., Jangra, S., Uccellini, M. B., Rathnasinghe, R., Coughlan, L., Martinez-Romero, C., Batra, J., Rojc, A., Bouhaddou, M., Fabius, J. M., Obernier, K., Dejosez, M., Guillén, M. J., Losada, A., Avilés, P., & 6 others , 26 Feb 2021, In: Science. 371, 6532, p. 926-931 6 p.Research output: Contribution to journal › Article › peer-review
Open Access149 Scopus citations -
Ronin governs the metabolic capacity of the embryonic lineage for post-implantation development
Salewskij, K., Gross-Thebing, T., Ing-Simmons, E., Duethorn, B., Rieger, B., Fan, R., Chen, R., Govindasamy, N., Brinkmann, H., Kremer, L., Kuempel-Rink, N., Mildner, K., Zeuschner, D., Stehling, M., Dejosez, M., Zwaka, T. P., Schöler, H. R., Busch, K. B., Vaquerizas, J. M. & Bedzhov, I., 4 Nov 2021, In: EMBO Reports. 22, 11, e53048.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Ronin overexpression induces cerebellar degeneration in a mouse model of ataxia
Zwaka, T. P., Skowronska, M., Richman, R. & Dejosez, M., Jun 2021, In: DMM Disease Models and Mechanisms. 14, 6, dmm044834.Research output: Contribution to journal › Article › peer-review
Open Access
Press / Media
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Ethics in medicine: International specialist society loosens rules for research on human embryos
29/05/21
1 item of Media coverage
Press/Media
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-The Peer Review journal Science confirms the potent activity of PharmaMar's plitidepsin against SARS-CoV-2
Kris White, & Thomas Zwaka
27/01/21
1 item of Media coverage
Press/Media
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Plitidepsine reduces 99% COVID viral load in laboratory tests
Kris White, & Thomas Zwaka
26/01/21
1 item of Media coverage
Press/Media