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PROFESSOR | Cell, Developmental & Regenerative Biology
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Research Topics http://icahn.mssm.edu/vgn-ext-templating/FapServlet?tab=far&rt=Apoptosis/Cell+Death&kw=&loc=&ips=&hrs=&g=&ln=&fn=&vgnextoid=24fc8af68fc17210VgnVCM1000003242020aRCRD&sitename=MSSM&fpa=true&inst= Apoptosis/Cell Death http://icahn.mssm.edu/vgn-ext-templating/FapServlet?tab=far&rt=Cell+Biology&kw=&loc=&ips=&hrs=&g=&ln=&fn=&vgnextoid=24fc8af68fc17210VgnVCM1000003242020aRCRD&sitename=MSSM&fpa=true&inst= Cell Biology http://icahn.mssm.edu/vgn-ext-templating/FapServlet?tab=far&rt=Developmental+Biology&kw=&loc=&ips=&hrs=&g=&ln=&fn=&vgnextoid=24fc8af68fc17210VgnVCM1000003242020aRCRD&sitename=MSSM&fpa=true&inst= Developmental Biology http://icahn.mssm.edu/vgn-ext-templating/FapServlet?tab=far&rt=Embryology&kw=&loc=&ips=&hrs=&g=&ln=&fn=&vgnextoid=24fc8af68fc17210VgnVCM1000003242020aRCRD&sitename=MSSM&fpa=true&inst= Embryology http://icahn.mssm.edu/vgn-ext-templating/FapServlet?tab=far&rt=Epigenetics&kw=&loc=&ips=&hrs=&g=&ln=&fn=&vgnextoid=24fc8af68fc17210VgnVCM1000003242020aRCRD&sitename=MSSM&fpa=true&inst= Epigenetics http://icahn.mssm.edu/vgn-ext-templating/FapServlet?tab=far&rt=Gene+Regulation&kw=&loc=&ips=&hrs=&g=&ln=&fn=&vgnextoid=24fc8af68fc17210VgnVCM1000003242020aRCRD&sitename=MSSM&fpa=true&inst= Gene Regulation http://icahn.mssm.edu/vgn-ext-templating/FapServlet?tab=far&rt=Gene+Therapy&kw=&loc=&ips=&hrs=&g=&ln=&fn=&vgnextoid=24fc8af68fc17210VgnVCM1000003242020aRCRD&sitename=MSSM&fpa=true&inst= Gene Therapy http://icahn.mssm.edu/vgn-ext-templating/FapServlet?tab=far&rt=Stem+Cells&kw=&loc=&ips=&hrs=&g=&ln=&fn=&vgnextoid=24fc8af68fc17210VgnVCM1000003242020aRCRD&sitename=MSSM&fpa=true&inst= Stem Cells http://icahn.mssm.edu/vgn-ext-templating/FapServlet?tab=far&rt=Tissue+Engineering&kw=&loc=&ips=&hrs=&g=&ln=&fn=&vgnextoid=24fc8af68fc17210VgnVCM1000003242020aRCRD&sitename=MSSM&fpa=true&inst= Tissue Engineering http://icahn.mssm.edu/vgn-ext-templating/FapServlet?tab=far&rt=Transcription+Factors&kw=&loc=&ips=&hrs=&g=&ln=&fn=&vgnextoid=24fc8af68fc17210VgnVCM1000003242020aRCRD&sitename=MSSM&fpa=true&inst= Transcription Factors http://icahn.mssm.edu/vgn-ext-templating/FapServlet?tab=far&rt=Transcriptional+Activation+and+Repression&kw=&loc=&ips=&hrs=&g=&ln=&fn=&vgnextoid=24fc8af68fc17210VgnVCM1000003242020aRCRD&sitename=MSSM&fpa=true&inst= Transcriptional Activation and Repression Training Areas http://icahn.mssm.edu/vgn-ext-templating/FapServlet?tab=far&ta=Developmental+and+Stem+Cell+Biology+[DSCB]&kw=&loc=&ips=&hrs=&g=&ln=&fn=&vgnextoid=24fc8af68fc17210VgnVCM1000003242020aRCRD&sitename=MSSM&fpa=true&inst= Developmental and Stem Cell Biology [DSCB] Education MD PhD, University of Ulm Postdoctoral, University of Wisconsin, Madison Research Pluripotency, Cellular Diversity, and Multicellularity Pluripotent stem cells can regenerate any tissue in the body, but the ability to direct these versatile cells toward specific medical endpoints, such as tissue repair or replacement, has been slow to develop. Our research is expected to accelerate the use of pluripotent stem cells in humans with injury or disease in a controlled, robust and predictable manner.
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Protection of early embryogenesis and pluripotent stem cells against genetic parasites through a primitive immune system
Zwaka, T. & Zwaka, T. P.
National Institute of Child Health and Human Development
23/03/20 → 28/02/23
Project: Research
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An inquiry into the function of Ronin in embryogenesis and pluripotent stem cells
National Institute of General Medical Sciences
11/07/18 → 31/03/19
Project: Research
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NON-APOPTOTIC ACTION OF CASPASES IN PLURIPOTENT EMBRYONIC STEM CELLS
National Institute of General Medical Sciences
1/08/08 → 31/05/14
Project: Research
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Thanatos-Associated Protein 11 (Thap11) in Human Embryonic Stem Cells
National Institute of General Medical Sciences
1/09/07 → 31/08/10
Project: Research
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Regulatory Networks in Human Embryonic Stem Cells
Goodell, M., Barton, M. A., Behringer, R. R., Cooney, A. J., Goodell, M. M. A., Zwaka, T., Zwaka, T. T. P. & Zwaka, T. P.
1/09/07 → 31/08/14
Project: Research
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Mutations in SARS-CoV-2 variants of concern link to increased spike cleavage and virus transmission
Escalera, A., Gonzalez-Reiche, A. S., Aslam, S., Mena, I., Laporte, M., Pearl, R. L., Fossati, A., Rathnasinghe, R., Alshammary, H., van de Guchte, A., Farrugia, K., Qin, Y., Bouhaddou, M., Kehrer, T., Zuliani-Alvarez, L., Meekins, D. A., Balaraman, V., McDowell, C., Richt, J. A., Bajic, G., & 9 others, 9 Mar 2022, In: Cell Host and Microbe. 30, 3, p. 373-387.e7Research output: Contribution to journal › Article › peer-review
Open Access40 Scopus citations -
Sec61 Inhibitor Apratoxin S4 Potently Inhibits SARS-CoV-2 and Exhibits Broad-Spectrum Antiviral Activity
Pohl, M. O., Martin-Sancho, L., Ratnayake, R., White, K. M., Riva, L., Chen, Q. Y., Lieber, G., Busnadiego, I., Yin, X., Lin, S., Pu, Y., Pache, L., Rosales, R., Déjosez, M., Qin, Y., De Jesus, P. D., Beall, A., Yoh, S., Hale, B. G., Zwaka, T. P., & 5 others, 8 Jul 2022, In: ACS Infectious Diseases. 8, 7, p. 1265-1279 15 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A
White, K. M., Rosales, R., Yildiz, S., Kehrer, T., Miorin, L., Moreno, E., Jangra, S., Uccellini, M. B., Rathnasinghe, R., Coughlan, L., Martinez-Romero, C., Batra, J., Rojc, A., Bouhaddou, M., Fabius, J. M., Obernier, K., Dejosez, M., Guillén, M. J., Losada, A., Avilés, P., & 6 others, 26 Feb 2021, In: Science. 371, 6532, p. 926-931 6 p.Research output: Contribution to journal › Article › peer-review
Open Access149 Scopus citations -
Ronin governs the metabolic capacity of the embryonic lineage for post-implantation development
Salewskij, K., Gross-Thebing, T., Ing-Simmons, E., Duethorn, B., Rieger, B., Fan, R., Chen, R., Govindasamy, N., Brinkmann, H., Kremer, L., Kuempel-Rink, N., Mildner, K., Zeuschner, D., Stehling, M., Dejosez, M., Zwaka, T. P., Schöler, H. R., Busch, K. B., Vaquerizas, J. M. & Bedzhov, I., 4 Nov 2021, In: EMBO Reports. 22, 11, e53048.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Ronin overexpression induces cerebellar degeneration in a mouse model of ataxia
Zwaka, T. P., Skowronska, M., Richman, R. & Dejosez, M., Jun 2021, In: DMM Disease Models and Mechanisms. 14, 6, dmm044834.Research output: Contribution to journal › Article › peer-review
Open Access
Press / Media
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Ethics in medicine: International specialist society loosens rules for research on human embryos
29/05/21
1 item of Media coverage
Press/Media
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-The Peer Review journal Science confirms the potent activity of PharmaMar's plitidepsin against SARS-CoV-2
Kris White, & Thomas Zwaka
27/01/21
1 item of Media coverage
Press/Media
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Plitidepsine reduces 99% COVID viral load in laboratory tests
Kris White, & Thomas Zwaka
26/01/21
1 item of Media coverage
Press/Media