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FOUNDING CHAIR EMERITUS AND PROFESSOR
Oncological Sciences

Biography

Stuart Aaronson, MD, is the Jack and Jane B. Aron Professor of Neoplastic Diseases; Founding Chair, Emeritus, Department of Oncological Sciences; and Associate Director of Basic and Translational Research at The Tisch Cancer Institute. Dr. Aaronson joined Mount Sinai in 1994 following a long tenure at the National Cancer Institute, during which he was Chief of the Laboratory of Cellular and Molecular Biology.

Dr. Aaronson participated in the discovery of the first normal function of an oncogene and the demonstration that genes encoding growth factors could be transforming (sis/PDGF). He subsequently discovered erbB2 as an erbB-related gene amplified in a primary human breast cancer, and genes for other growth factor signaling molecules activated as oncogenes in human malignancies. Dr. Aaronson’s research has contributed to the development of novel cancer drugs including Herceptin which targets ERBB2, and KGF/FGF7, discovered by him as a unique epithelial cell acting growth factor and which became a drug for treatment of mucositis, a debilitating side effect of certain cancer therapies. His discoveries, including erbB3, PDGFR alpha, and HGF as the ligand for MET, have led to other approved drugs as well as those currently in clinical development as cancer therapeutics. More recently, Dr. Aaronson identified a Wnt autocrine activation mechanism, which helps to drive the malignant phenotype of some human breast, ovary, lung, and soft tissue tumors.

Dr. Aaronson is the recipient of numerous awards including the Distinguished Service Medal from the U.S. Public Health Service, the AACR Award for Outstanding Achievement in Cancer Research, and the Paul Erhlich Prize from Germany. He is the author of more than 485 publications, an inventor on more than 40 patents, and serves on numerous editorial boards and scientific advisory committees. He has trained dozens of investigators, who have gone on to positions in academic medicine or biotech/pharma, or who head cancer centers in this country and abroad. 

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  • Apoptotic cell death in disease—Current understanding of the NCCD 2023

    Vitale, I., Pietrocola, F., Guilbaud, E., Aaronson, S. A., Abrams, J. M., Adam, D., Agostini, M., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., Aqeilan, R. I., Arama, E., Baehrecke, E. H., Balachandran, S., Bano, D., Barlev, N. A., Bartek, J., Bazan, N. G., & 208 othersBecker, C., Bernassola, F., Bertrand, M. J. M., Bianchi, M. E., Blagosklonny, M. V., Blander, J. M., Blandino, G., Blomgren, K., Borner, C., Bortner, C. D., Bove, P., Boya, P., Brenner, C., Broz, P., Brunner, T., Damgaard, R. B., Calin, G. A., Campanella, M., Candi, E., Carbone, M., Carmona-Gutierrez, D., Cecconi, F., Chan, F. K. M., Chen, G. Q., Chen, Q., Chen, Y. H., Cheng, E. H., Chipuk, J. E., Cidlowski, J. A., Ciechanover, A., Ciliberto, G., Conrad, M., Cubillos-Ruiz, J. R., Czabotar, P. E., D’Angiolella, V., Daugaard, M., Dawson, T. M., Dawson, V. L., De Maria, R., De Strooper, B., Debatin, K. M., Deberardinis, R. J., Degterev, A., Del Sal, G., Deshmukh, M., Di Virgilio, F., Diederich, M., Dixon, S. J., Dynlacht, B. D., El-Deiry, W. S., Elrod, J. W., Engeland, K., Fimia, G. M., Galassi, C., Ganini, C., Garcia-Saez, A. J., Garg, A. D., Garrido, C., Gavathiotis, E., Gerlic, M., Ghosh, S., Green, D. R., Greene, L. A., Gronemeyer, H., Häcker, G., Hajnóczky, G., Hardwick, J. M., Haupt, Y., He, S., Heery, D. M., Hengartner, M. O., Hetz, C., Hildeman, D. A., Ichijo, H., Inoue, S., Jäättelä, M., Janic, A., Joseph, B., Jost, P. J., Kanneganti, T. D., Karin, M., Kashkar, H., Kaufmann, T., Kelly, G. L., Kepp, O., Kimchi, A., Kitsis, R. N., Klionsky, D. J., Kluck, R., Krysko, D. V., Kulms, D., Kumar, S., Lavandero, S., Lavrik, I. N., Lemasters, J. J., Liccardi, G., Linkermann, A., Lipton, S. A., Lockshin, R. A., López-Otín, C., Luedde, T., MacFarlane, M., Madeo, F., Malorni, W., Manic, G., Mantovani, R., Marchi, S., Marine, J. C., Martin, S. J., Martinou, J. C., Mastroberardino, P. G., Medema, J. P., Mehlen, P., Meier, P., Melino, G., Melino, S., Miao, E. A., Moll, U. M., Muñoz-Pinedo, C., Murphy, D. J., Niklison-Chirou, M. V., Novelli, F., Núñez, G., Oberst, A., Ofengeim, D., Opferman, J. T., Oren, M., Pagano, M., Panaretakis, T., Pasparakis, M., Penninger, J. M., Pentimalli, F., Pereira, D. M., Pervaiz, S., Peter, M. E., Pinton, P., Porta, G., Prehn, J. H. M., Puthalakath, H., Rabinovich, G. A., Rajalingam, K., Ravichandran, K. S., Rehm, M., Ricci, J. E., Rizzuto, R., Robinson, N., Rodrigues, C. M. P., Rotblat, B., Rothlin, C. V., Rubinsztein, D. C., Rudel, T., Rufini, A., Ryan, K. M., Sarosiek, K. A., Sawa, A., Sayan, E., Schroder, K., Scorrano, L., Sesti, F., Shao, F., Shi, Y., Sica, G. S., Silke, J., Simon, H. U., Sistigu, A., Stephanou, A., Stockwell, B. R., Strapazzon, F., Strasser, A., Sun, L., Sun, E., Sun, Q., Szabadkai, G., Tait, S. W. G., Tang, D., Tavernarakis, N., Troy, C. M., Turk, B., Urbano, N., Vandenabeele, P., Vanden Berghe, T., Vander Heiden, M. G., Vanderluit, J. L., Verkhratsky, A., Villunger, A., von Karstedt, S., Voss, A. K., Vousden, K. H., Vucic, D., Vuri, D., Wagner, E. F., Walczak, H., Wallach, D., Wang, R., Wang, Y., Weber, A., Wood, W., Yamazaki, T., Yang, H. T., Zakeri, Z., Zawacka-Pankau, J. E., Zhang, L., Zhang, H., Zhivotovsky, B., Zhou, W., Piacentini, M., Kroemer, G. & Galluzzi, L., May 2023, In: Cell Death and Differentiation. 30, 5, p. 1097-1154 58 p.

    Research output: Contribution to journalReview articlepeer-review

    Open Access
    82 Scopus citations
  • Global DNA methylation of WTC prostate cancer tissues show signature differences compared to non-exposed cases

    Yu, H., Tuminello, S., Alpert, N., Van Gerwen, M., Yoo, S., Mulholland, D. J., Aaronson, S. A., Donovan, M., Oh, W. K., Gong, Y., Wang, L., Zhu, J. & Taioli, E., 1 Jun 2022, In: Carcinogenesis. 43, 6, p. 528-537 10 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    3 Scopus citations
  • Patient-specific MDS-RS iPSCs define the mis-spliced transcript repertoire and chromatin landscape of SF3B1-mutant HSPCs

    Asimomitis, G., Deslauriers, A. G., Kotini, A. G., Bernard, E., Esposito, D., Olszewska, M., Spyrou, N., Ossa, J. A., Mortera-Blanco, T., Koche, R., Nannya, Y., Malcovati, L., Ogawa, S., Cazzola, M., Aaronson, S. A., Hellström-Lindberg, E., Papaemmanuil, E. & Papapetrou, E. P., 24 May 2022, In: Blood advances. 6, 10, p. 2992-3005 14 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    5 Scopus citations
  • ROCK1 mechano-signaling dependency of human malignancies driven by TEAD/YAP activation

    Esposito, D., Pant, I., Shen, Y., Qiao, R. F., Yang, X., Bai, Y., Jin, J., Poulikakos, P. I. & Aaronson, S. A., Dec 2022, In: Nature Communications. 13, 1, 703.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    25 Scopus citations
  • Distinct CDK6 complexes determine tumor cell response to CDK4/6 inhibitors and degraders

    Wu, X., Yang, X., Xiong, Y., Li, R., Ito, T., Ahmed, T. A., Karoulia, Z., Adamopoulos, C., Wang, H., Wang, L., Xie, L., Liu, J., Ueberheide, B., Aaronson, S. A., Chen, X., Buchanan, S. G., Sellers, W. R., Jin, J. & Poulikakos, P. I., Apr 2021, In: Nature Cancer. 2, 4, p. 429-443 15 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    30 Scopus citations